Total Body Irradiation without Chemotherapy as Conditioning for an Allogeneic Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia
Joint Authors
Allan, David
Altouri, Sultan
Sabloff, Mitchell
Atkins, Harry
Huebsch, Lothar
Maze, Dawn
Samant, Rajiv
Bredeson, Christopher
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Current therapies for acute myeloid leukemia (AML), failing induction, are rarely effective.
We report our experience in 4 patients with AML who received 16 Gy TBI prior to allogeneic hematopoietic cell transplantation (alloHCT), between June 2010 and May 2011.
Patients were 20 to 55 years of age, 2 with relapsed disease and 2 with AML failing induction.
An HLA-matched graft from related or unrelated donor was infused on day 0.
All but one, who received a CD34+-selected graft, received methotrexate and tacrolimus +/− antithymocyte globulin, as GVHD prophylaxis.
The other patient received tacrolimus alone.
Neutrophil and platelet engraftment occurred at a median of 18 and 14 days, respectively.
Patients were discharged at a median of 28 days.
There were no unexpected toxicities in the first 30 days.
One patient had cytomegalovirus (CMV) viremia and anorexia, at two months.
One patient had grade 2 acute GVHD of the skin.
One patient developed chronic GVHD of the eyes, mouth, skin, joints, and lung at 4 months.
Two patients died from relapse of their leukemia at days 65 and 125.
Two patients remain in remission beyond day 1500.
16 Gy TBI followed by an alloHCT for AML, failing induction, is feasible and tolerable.
American Psychological Association (APA)
Altouri, Sultan& Sabloff, Mitchell& Allan, David& Atkins, Harry& Huebsch, Lothar& Maze, Dawn…[et al.]. 2016. Total Body Irradiation without Chemotherapy as Conditioning for an Allogeneic Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1100829
Modern Language Association (MLA)
Altouri, Sultan…[et al.]. Total Body Irradiation without Chemotherapy as Conditioning for an Allogeneic Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia. Case Reports in Hematology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1100829
American Medical Association (AMA)
Altouri, Sultan& Sabloff, Mitchell& Allan, David& Atkins, Harry& Huebsch, Lothar& Maze, Dawn…[et al.]. Total Body Irradiation without Chemotherapy as Conditioning for an Allogeneic Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1100829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100829