T CellHistiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall
Joint Authors
Xu, Jie
Wu, Xiaojun
Reddy, Vishnu V. B.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
T cell/histiocyte-rich large B cell lymphoma (THRLBCL) is predominantly a nodal disease, with extranodal involvement, such as bone marrow, spleen, and liver.
However, primary THRLBCL has never been reported in the thymus in the English literature.
Here we report a case of THRLBCL presenting as mediastinal mass and lymphadenopathy.
Based on the frozen section diagnosis of “thymoma,” a 12 cm mass was excised.
A year later she developed multiple enlarged lymph nodes and pulmonary nodules.
Consultant review of the excised mediastinal mass showed scattered large atypical cells that were CD20+ and PAX-5+ and negative for pan-cytokeratin, AE1, and AE3, compatible with THRLBCL and excluding thymoma.
The excised lymph nodes were replaced by diffuse infiltrate of small CD3+ lymphocytes and histiocytes with intermingled large CD20+ B lymphoma cells scattered throughout the section.
A diagnosis of THRLBCL was made in lymph node, similar to previous thymic lesion.
A clonal rearrangement of immunoglobulin heavy chain (IGH) gene was detected, further supporting the diagnosis.
This is the first reported case of THRLBCL in thymus.
Correct recognition of this entity is critical, because of the difference in therapeutic impact on these patients.
American Psychological Association (APA)
Xu, Jie& Wu, Xiaojun& Reddy, Vishnu V. B.. 2016. T CellHistiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1100842
Modern Language Association (MLA)
Xu, Jie…[et al.]. T CellHistiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall. Case Reports in Hematology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1100842
American Medical Association (AMA)
Xu, Jie& Wu, Xiaojun& Reddy, Vishnu V. B.. T CellHistiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1100842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100842