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TAFRO Syndrome Associated with EBV and Successful Triple Therapy Treatment: Case Report and Review of the Literature
Joint Authors
Simons, Malorie
Apor, Emmanuel
Treaba, Diana O.
Butera, James N.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
TAFRO syndrome is a rare constellation of symptoms: thrombocytopenia, anasarca, reticulin fibrosis of the bone marrow, renal dysfunction, and organomegaly.
Its pathogenesis involves an excessive and inappropriate cytokine storm, most notably from IL-6, causing multiorgan failure; however, its etiology is undetermined.
Starting in 2012, TAFRO syndrome was first identified in Japan as an atypical variant of Castleman’s disease.
Previous reports include various different treatment protocols with inconsistent survival outcomes.
Here we report the first known American, EBV positive but HIV and HHV-8 negative, male with TAFRO syndrome.
He was successfully treated with an unusual three-drug regimen including tocilizumab, etoposide, and rituximab.
We review the literature of TAFRO syndrome, discuss its possible viral etiology, and propose an original treatment regimen.
American Psychological Association (APA)
Simons, Malorie& Apor, Emmanuel& Butera, James N.& Treaba, Diana O.. 2016. TAFRO Syndrome Associated with EBV and Successful Triple Therapy Treatment: Case Report and Review of the Literature. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1100857
Modern Language Association (MLA)
Simons, Malorie…[et al.]. TAFRO Syndrome Associated with EBV and Successful Triple Therapy Treatment: Case Report and Review of the Literature. Case Reports in Hematology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1100857
American Medical Association (AMA)
Simons, Malorie& Apor, Emmanuel& Butera, James N.& Treaba, Diana O.. TAFRO Syndrome Associated with EBV and Successful Triple Therapy Treatment: Case Report and Review of the Literature. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1100857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100857