Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma
Joint Authors
Van Keer, Jan
Sprangers, Ben
Delforge, Michel
Peerlinck, Kathelijne
Lerut, Evelyne
Dierickx, D.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Bortezomib is a first-generation proteasome inhibitor used in the treatment of multiple myeloma (MM).
A few reports have linked bortezomib exposure with the development of thrombotic microangiopathy (TMA).
We describe a case of biopsy-proven renal thrombotic microangiopathy associated with the use of bortezomib in a 51-year-old man with IgG lambda MM.
To our knowledge, this is the first biopsy-proven case.
In addition, reexposure to bortezomib 18 months later was associated with recurrence of TMA.
This supports a possible causal role of bortezomib.
The exact mechanisms remain to be elucidated.
American Psychological Association (APA)
Van Keer, Jan& Delforge, Michel& Dierickx, D.& Peerlinck, Kathelijne& Lerut, Evelyne& Sprangers, Ben. 2016. Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100864
Modern Language Association (MLA)
Van Keer, Jan…[et al.]. Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma. Case Reports in Hematology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1100864
American Medical Association (AMA)
Van Keer, Jan& Delforge, Michel& Dierickx, D.& Peerlinck, Kathelijne& Lerut, Evelyne& Sprangers, Ben. Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100864
