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A Case of De Novo CD5+ Disseminated Intravascular Large B-Cell Lymphoma Presenting as Multiorgan Failure
Joint Authors
Singh, Daulath
Kapuria, Devika
Nanua, Suparna
Gaur, Rakesh
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Intravascular large B-cell lymphoma is an extremely rare extranodal lymphoma that proliferates in the lumen of the blood vessels while sparing the organ parenchyma.
It usually presents with CNS and skin involvement.
A 65-year-old Caucasian female presented with fevers and chills of 3-4 months’ duration.
Bone marrow biopsy done 3 months prior showed no significant myelodysplasia or lymphoid aggregates.
The patient later died due to multiorgan failure.
A bone marrow biopsy showed 20–30% CD5+ B cells consistent with infiltrative large B-cell lymphoma.
An autopsy performed revealed diffuse intravascular invasion by lymphoma cells.
Multiorgan involvement by intravascular B-cell lymphoma is very rare.
Based on our literature review and to the best of our knowledge, there are only 5 case reports describing the presentation of this lymphoma with multiorgan failure.
The immunophenotypic studies performed revealed that our patient had de novo CD5+ intravascular large B-cell lymphoma which is known to be aggressive with very poor prognosis.
Although it is an extremely rare lymphoma, it should be considered as a potential cause of multiorgan failure when no other cause has been identified.
A prompt tissue diagnosis and high-dose chemotherapy followed by ASCT can sometimes achieve remission.
American Psychological Association (APA)
Singh, Daulath& Kapuria, Devika& Nanua, Suparna& Gaur, Rakesh. 2016. A Case of De Novo CD5+ Disseminated Intravascular Large B-Cell Lymphoma Presenting as Multiorgan Failure. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100868
Modern Language Association (MLA)
Singh, Daulath…[et al.]. A Case of De Novo CD5+ Disseminated Intravascular Large B-Cell Lymphoma Presenting as Multiorgan Failure. Case Reports in Hematology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1100868
American Medical Association (AMA)
Singh, Daulath& Kapuria, Devika& Nanua, Suparna& Gaur, Rakesh. A Case of De Novo CD5+ Disseminated Intravascular Large B-Cell Lymphoma Presenting as Multiorgan Failure. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100868