Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia
Joint Authors
Kelly, Johanna
Haslam, Karl
Flavin, Richard
Andrews, Claire
Ryan, Ciara
Hayden, Patrick J.
Bacon, Christopher L.
Langabeer, Stephen E.
O'Brien, David
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The development of acute lymphoblastic leukemia in an existing myeloproliferative neoplasm is rare with historical cases unable to differentiate between concomitant malignancies or leukemic transformation.
Molecular studies of coexisting JAK2 V617F-positive myeloproliferative neoplasms and mature B cell malignancies indicate distinct disease entities arising in myeloid and lymphoid committed hematopoietic progenitor cells, respectively.
Mutations of CALR in essential thrombocythemia appear to be associated with a distinct phenotype and a lower risk of thrombosis yet their impact on disease progression is less well defined.
The as yet undescribed scenario of pro-B cell acute lymphoblastic leukemia arising in CALR mutated essential thrombocythemia is presented.
Intensive treatment for the leukemia allowed for expansion of the original CALR mutated clone.
Whether CALR mutations in myeloproliferative neoplasms predispose to the acquisition of additional malignancies, particularly lymphoproliferative disorders, is not yet known.
American Psychological Association (APA)
Langabeer, Stephen E.& Haslam, Karl& O'Brien, David& Kelly, Johanna& Andrews, Claire& Ryan, Ciara…[et al.]. 2016. Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100870
Modern Language Association (MLA)
Langabeer, Stephen E.…[et al.]. Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia. Case Reports in Hematology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1100870
American Medical Association (AMA)
Langabeer, Stephen E.& Haslam, Karl& O'Brien, David& Kelly, Johanna& Andrews, Claire& Ryan, Ciara…[et al.]. Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100870