Uveitis and Myositis as Immune Complications in Chemorefractory NKT-Cell Nasal-Type Lymphoma Successfully Treated with Allogeneic Stem-Cell Transplant
Joint Authors
Gómez-Crespo, Maria José
García-Raso, Aránzazu
López-Lorenzo, Jose Luis
Villaescusa, Teresa
Rodríguez-Pinilla, María
Fortes, José
Serrano, Cristina
Machan, Salma
Llamas, Pilar
Córdoba, Raúl
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
NK/T-cell lymphomas are a group of clonal proliferations of NK- or, rarely, T-cell types and have peculiar clinicopathologic features.
Most common site of involvement is the upper aerodigestive tract (nasal cavity, nasopharynx, paranasal sinuses, and palate).
Association of autoimmune paraneoplastic disorders with NK/T-cell lymphomas is not well studied.
Our patient was diagnosed with NK/T-cell lymphoma stage IV with skin involvement and treated frontline with CHOEP regimen.
While he was under treatment, two immune complications presented: anterior uveitis of autoimmune origin refractory to steroids and myositis in lower limbs muscles.
Autologous transplantation was rejected due to confirmed early relapse after first-line treatment, and the patient received second-line treatment according to the SMILE scheme, reaching complete response after four cycles.
The patient underwent allogeneic transplantation and at the time of manuscript preparation is alive despite multiple complications.
The disease should be suspected in patients with rhinitis or recurrent sinusitis, and early biopsy is recommended for all patients to avoid a delay in diagnosis.
Our patient also presented symptoms of disease progression after first-line treatment, representing a paraneoplastic process, a very rare phenomenon in T-type lymphomas.
This case is novel for the appearance of an inflammatory myositis, a histologically verified paraneoplastic phenomenon that responded to treatment for lymphoma.
American Psychological Association (APA)
Gómez-Crespo, Maria José& García-Raso, Aránzazu& López-Lorenzo, Jose Luis& Villaescusa, Teresa& Rodríguez-Pinilla, María& Fortes, José…[et al.]. 2016. Uveitis and Myositis as Immune Complications in Chemorefractory NKT-Cell Nasal-Type Lymphoma Successfully Treated with Allogeneic Stem-Cell Transplant. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100877
Modern Language Association (MLA)
Gómez-Crespo, Maria José…[et al.]. Uveitis and Myositis as Immune Complications in Chemorefractory NKT-Cell Nasal-Type Lymphoma Successfully Treated with Allogeneic Stem-Cell Transplant. Case Reports in Hematology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1100877
American Medical Association (AMA)
Gómez-Crespo, Maria José& García-Raso, Aránzazu& López-Lorenzo, Jose Luis& Villaescusa, Teresa& Rodríguez-Pinilla, María& Fortes, José…[et al.]. Uveitis and Myositis as Immune Complications in Chemorefractory NKT-Cell Nasal-Type Lymphoma Successfully Treated with Allogeneic Stem-Cell Transplant. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100877