Sjögren’s Syndrome Complicated by MyeloidNatural Killer Cell Precursor Acute Leukemia: Case Report and Review of the Literature
Joint Authors
Feng, Hao
Qiao, Jianlin
Ding, Ningning
Chen, Wei
Qi, Kunming
Pan, Xiuying
Cao, Jiang
Xu, Kailin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-04
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
We report a case of Sjögren’s syndrome (SS) complicated by myeloid/natural killer (NK) cell precursor acute leukemia (M/NKPAL).
A 75-year-old woman with a previous SS history for 2 years was routinely treated.
Peripheral blood progenitor cells were increased, and subsequent bone marrow cell morphology examination showed the presence of acute myeloid leukemia type M4.
However, flow cytometry analysis revealed that CD7/CD56/CD33/CD34/HLA-DR/cCD3 were all positive and myeloperoxidase- (MPO-) specific staining, other T cells, NK cells, and myeloid markers were all negative.
Clonal T-cell receptor (TCR)β/TCRγ/TCRδ gene rearrangements and Epstein-Barr virus (EBV) were negative.
The diagnosis of M/NKPAL was therefore confirmed.
Unfortunately, this patient did not receive chemotherapy and later died of acute left heart failure and respiratory failure.
SS complication with M/NKPAL is relatively rare.
Combined with the relevant literatures, our study offers new insights into the clinical characteristics, pathological features, possible pathogenesis, and differential diagnosis of this rare disease.
American Psychological Association (APA)
Feng, Hao& Qiao, Jianlin& Ding, Ningning& Chen, Wei& Qi, Kunming& Pan, Xiuying…[et al.]. 2016. Sjögren’s Syndrome Complicated by MyeloidNatural Killer Cell Precursor Acute Leukemia: Case Report and Review of the Literature. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100888
Modern Language Association (MLA)
Feng, Hao…[et al.]. Sjögren’s Syndrome Complicated by MyeloidNatural Killer Cell Precursor Acute Leukemia: Case Report and Review of the Literature. Case Reports in Hematology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100888
American Medical Association (AMA)
Feng, Hao& Qiao, Jianlin& Ding, Ningning& Chen, Wei& Qi, Kunming& Pan, Xiuying…[et al.]. Sjögren’s Syndrome Complicated by MyeloidNatural Killer Cell Precursor Acute Leukemia: Case Report and Review of the Literature. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100888