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Mantle Cell Hyperplasia of Peripheral Lymph Nodes as Initial Manifestation of Sickle Cell Disease
Joint Authors
Monabbati, Ahmad
Noori, Sadat
Safaei, Akbar
Ramzi, Mani
Adib, Ali
Eghbali, Seyed Sajjad
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Sickle cell disease (SCD) is a well known hemoglobinopathy with usual manifestations including anemia, hyperbilirubinemia, and vasoocclusive complications.
Despite presence of mild splenomegaly in early phase of the disease, lymphadenopathy is not an often finding of SCD.
We introduce an undiagnosed case of SCD who presented in third decade of his life with multiple cervical lymphadenopathies and mild splenomegaly persistent for about five years.
Histopathologic examination of the resected lymph nodes showed expansion of the mantle cell layers of secondary follicles as well as several monomorphic mantle cell nodules.
To rule out possibility of a malignant process involving lymph nodes, an immunohistochemical panel was ordered which was in favor of benign mantle cell hyperplasia.
Immunoglobulin gene rearrangement study showed no clonal bands and confirmed benign nature of the process.
Respecting mild abnormalities on Complete Blood Count, peripheral blood smear was reviewed revealing some typical sickle red blood cells as well as rare nucleated red blood cells.
Solubility test for hemoglobin (HB) S was positive.
Hemoglobin electrophoresis confirmed diagnosis of homozygous HbS disease.
American Psychological Association (APA)
Monabbati, Ahmad& Noori, Sadat& Safaei, Akbar& Ramzi, Mani& Eghbali, Seyed Sajjad& Adib, Ali. 2016. Mantle Cell Hyperplasia of Peripheral Lymph Nodes as Initial Manifestation of Sickle Cell Disease. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100890
Modern Language Association (MLA)
Monabbati, Ahmad…[et al.]. Mantle Cell Hyperplasia of Peripheral Lymph Nodes as Initial Manifestation of Sickle Cell Disease. Case Reports in Hematology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100890
American Medical Association (AMA)
Monabbati, Ahmad& Noori, Sadat& Safaei, Akbar& Ramzi, Mani& Eghbali, Seyed Sajjad& Adib, Ali. Mantle Cell Hyperplasia of Peripheral Lymph Nodes as Initial Manifestation of Sickle Cell Disease. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100890