Treatment of Polymicrobial Osteomyelitis with Ceftolozane-Tazobactam: Case Report and Sensitivity Testing of Isolates
Joint Authors
Joson, Jeremiah
Heidari, Arash
Jolliff, Jeffrey C.
Ho, Jackie
Johnson, Royce
Source
Case Reports in Infectious Diseases
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Stenotrophomonas maltophilia is an inherently multidrug resistant (MDR) opportunistic pathogen with many mechanisms of resistance.
SENTRY studies reveal decreasing sensitivities of S.
maltophilia to trimethoprim-sulfamethoxazole and fluoroquinolones.
Ceftolozane-tazobactam (Zerbaxa, Merck & Co., Inc.) a novel intravenous combination agent of a third-generation cephalosporin and β-lactamase inhibitor was demonstrated to have in vitro activity against many Gram-positive, Gram-negative, and MDR organisms.
Data for ceftolozane-tazobactam’s use outside of Food and Drug Administration (FDA) approved indications has been limited thus far to two case reports which demonstrated its efficacy in pan-resistant Pseudomonas aeruginosa pneumonia.
Herein, we describe the first published case of treatment of MDR S.
maltophilia in polymicrobial osteomyelitis with long-term (>14 days) ceftolozane-tazobactam and metronidazole.
Ceftolozane-tazobactam may offer a possible alternative for clinicians faced with limited options in the treatment of resistant pathogens including MDR S.
maltophilia.
American Psychological Association (APA)
Jolliff, Jeffrey C.& Ho, Jackie& Joson, Jeremiah& Heidari, Arash& Johnson, Royce. 2016. Treatment of Polymicrobial Osteomyelitis with Ceftolozane-Tazobactam: Case Report and Sensitivity Testing of Isolates. Case Reports in Infectious Diseases،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100938
Modern Language Association (MLA)
Jolliff, Jeffrey C.…[et al.]. Treatment of Polymicrobial Osteomyelitis with Ceftolozane-Tazobactam: Case Report and Sensitivity Testing of Isolates. Case Reports in Infectious Diseases No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100938
American Medical Association (AMA)
Jolliff, Jeffrey C.& Ho, Jackie& Joson, Jeremiah& Heidari, Arash& Johnson, Royce. Treatment of Polymicrobial Osteomyelitis with Ceftolozane-Tazobactam: Case Report and Sensitivity Testing of Isolates. Case Reports in Infectious Diseases. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100938