A Rare Complication of Trimethoprim-Sulfamethoxazole: Drug Induced Aseptic Meningitis
Joint Authors
Jha, Pinky
Stromich, Jeremiah
Cohen, Mallory
Wainaina, Jane Njeri
Source
Case Reports in Infectious Diseases
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-07
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Drug induced aseptic meningitis is a rare but challenging diagnosis, most commonly reported with nonsteroidal anti-inflammatory drugs and antibiotics.
Trimethoprim/sulfamethoxazole is a sulfonamide that is widely used in clinical practice for the treatment and prophylaxis of various infections.
Drug induced aseptic meningitis, when seen with trimethoprim/sulfamethoxazole, occurs predominantly in patients with some degree of immune compromise and is less commonly seen in immune competent individuals.
The patient often exhibits the classic symptoms of meningitis.
Early diagnosis is important, since the cessation of the antibiotic leads to rapid clinical improvement.
Trimethoprim/sulfamethoxazole induced aseptic meningitis has been underreported to FDA/MED-WATCH program.
Here we report two cases of trimethoprim/sulfamethoxazole: an immune competent individual and immune compromised individual, both of which presented with signs of meningitis and a negative infectious workup.
Trimethoprim/sulfamethoxazole is an uncommon and mysterious adverse reaction to a commonly used antibiotic.
It should be considered in the differential diagnosis of patients presenting with acute signs and symptoms of meningitis especially after infectious causes have been ruled out.
American Psychological Association (APA)
Jha, Pinky& Stromich, Jeremiah& Cohen, Mallory& Wainaina, Jane Njeri. 2016. A Rare Complication of Trimethoprim-Sulfamethoxazole: Drug Induced Aseptic Meningitis. Case Reports in Infectious Diseases،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100972
Modern Language Association (MLA)
Jha, Pinky…[et al.]. A Rare Complication of Trimethoprim-Sulfamethoxazole: Drug Induced Aseptic Meningitis. Case Reports in Infectious Diseases No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100972
American Medical Association (AMA)
Jha, Pinky& Stromich, Jeremiah& Cohen, Mallory& Wainaina, Jane Njeri. A Rare Complication of Trimethoprim-Sulfamethoxazole: Drug Induced Aseptic Meningitis. Case Reports in Infectious Diseases. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100972