On-Treatment Elevation in Hepatic Transaminases during HCV Treatment with Ombitasvir, Paritaprevir, Dasabuvir, Ritonavir, and Ribavirin: A Case Series
Joint Authors
Bean, Madelyne
Tang, Lydia
Kottilil, Shyam
Beavers, Kimberly L.
Meissner, Eric G.
Source
Case Reports in Infectious Diseases
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Eradication of chronic hepatitis C virus (HCV) infection is now possible with all oral antiviral medications, including the combination of ombitasvir, paritaprevir, dasabuvir, and ritonavir (PrOD) with or without ribavirin.
While high rates of sustained virologic response (SVR) can be achieved, a small subset of patients experience on-treatment liver enzyme elevations, in particular women using concurrent estradiol-containing oral contraceptive medications (OCPs).
Herein, we describe four cases of liver enzyme elevations within 2-3 weeks of PrOD initiation in African-American men infected with HCV genotype 1a or 1b.
Three patients with varying degrees of hepatic fibrosis received a full treatment course without medication modification, achieved SVR, and experienced resolution of liver enzyme abnormalities.
One patient with cirrhosis was switched mid-treatment to an alternate HCV regimen, experienced subsequent resolution of liver enzyme abnormalities, and achieved SVR.
In summary, these cases suggest that all HCV patients treated with PrOD, independent of gender or concurrent medications, should have laboratory monitoring for liver enzyme elevations, with a particular emphasis on early monitoring in cirrhotic patients.
American Psychological Association (APA)
Bean, Madelyne& Tang, Lydia& Kottilil, Shyam& Beavers, Kimberly L.& Meissner, Eric G.. 2016. On-Treatment Elevation in Hepatic Transaminases during HCV Treatment with Ombitasvir, Paritaprevir, Dasabuvir, Ritonavir, and Ribavirin: A Case Series. Case Reports in Infectious Diseases،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101002
Modern Language Association (MLA)
Bean, Madelyne…[et al.]. On-Treatment Elevation in Hepatic Transaminases during HCV Treatment with Ombitasvir, Paritaprevir, Dasabuvir, Ritonavir, and Ribavirin: A Case Series. Case Reports in Infectious Diseases No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1101002
American Medical Association (AMA)
Bean, Madelyne& Tang, Lydia& Kottilil, Shyam& Beavers, Kimberly L.& Meissner, Eric G.. On-Treatment Elevation in Hepatic Transaminases during HCV Treatment with Ombitasvir, Paritaprevir, Dasabuvir, Ritonavir, and Ribavirin: A Case Series. Case Reports in Infectious Diseases. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101002