Severe Agranulocytosis following Simultaneous Administration of Chlorpromazine and Trimethoprim-Sulfamethoxazole in a Patient with Sepsis: A Possible Toxic Combination
Joint Authors
Jha, Anil
Ghoz, Hassan
James, Nicholas
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-18
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
Chlorpromazine and trimethoprim-sulfamethoxazole (TMP/SMX) are two commonly prescribed medications by physicians.
Either of those medications could cause fatal drug-induced agranulocytosis, with an unclear underlying mechanism.
The likelihood of simultaneous prescription of both medications is high and could hypothetically result in severe agranulocytosis that is resistant to treatment.
Case Presentation.
We are presenting a case of a patient with psychosis on chlorpromazine who was prescribed TMP/SMX for a urinary tract infection.
Consequently, the patient developed severe agranulocytosis and septicemia.
Patient was managed by granulocyte colony-stimulating factor; however, the time to neutrophil recovery was delayed when compared to the average reported time published by previous studies.
Conclusions.
Simultaneous use of chlorpromazine and TMP/SMX is a possible toxic combination that could induce severe agranulocytosis.
Further reports are needed to confirm this observation.
American Psychological Association (APA)
Jha, Anil& Ghoz, Hassan& James, Nicholas. 2016. Severe Agranulocytosis following Simultaneous Administration of Chlorpromazine and Trimethoprim-Sulfamethoxazole in a Patient with Sepsis: A Possible Toxic Combination. Case Reports in Medicine،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1101130
Modern Language Association (MLA)
Jha, Anil…[et al.]. Severe Agranulocytosis following Simultaneous Administration of Chlorpromazine and Trimethoprim-Sulfamethoxazole in a Patient with Sepsis: A Possible Toxic Combination. Case Reports in Medicine No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1101130
American Medical Association (AMA)
Jha, Anil& Ghoz, Hassan& James, Nicholas. Severe Agranulocytosis following Simultaneous Administration of Chlorpromazine and Trimethoprim-Sulfamethoxazole in a Patient with Sepsis: A Possible Toxic Combination. Case Reports in Medicine. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1101130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101130