Rapidly Progressing Refractory Hodgkin Lymphoma: A Case Report and a Possible Explanation
Joint Authors
Váróczy, László
Jóna, Ádám
Irsai, Gábor
Barna, Sándor
Méhes, Gábor
Illés, Árpád
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Introduction.
Hodgkin lymphoma is a highly curable lymphoid malignancy; however treatment of a significant number of patients remains challenging.
Case Report.
The authors present an unusually rapidly progressing case of refractory advanced stage classical nodular sclerosis subtype Hodgkin lymphoma with unfavorable prognosis.
A 66-year-old male patient was refractory for first-line doxorubicin, bleomycin, vinblastin, dacarbazine (ABVD) treatment with persistent disease; therefore physicians changed treatment for dexamethasone, cytarabine, and cisplatin (DHAP) and later ifosfamide, gemcitabine, and vinorelbine (IGEV) regimen.
Unfortunately the patient developed acute kidney and respiratory failure and died after 6 months of treatment.
Current and retrospective histological examination of the patient’s lymph node biopsy, skin lesion, and autopsy revealed the same aberrantly expressing CD4 positive nodular sclerosis subtype Hodgkin lymphoma.
Conclusion.
Aberrant expression of T-cell antigens on the Hodgkin and Reed/Sternberg cells could be associated with inferior outcome.
T-cell associated antigens should be investigated more often in patients not responding sufficiently to treatment and hence treatment should be intensified or targeted therapy (brentuximab vedotin) should be considered.
American Psychological Association (APA)
Jóna, Ádám& Irsai, Gábor& Barna, Sándor& Méhes, Gábor& Illés, Árpád& Váróczy, László. 2016. Rapidly Progressing Refractory Hodgkin Lymphoma: A Case Report and a Possible Explanation. Case Reports in Medicine،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101159
Modern Language Association (MLA)
Jóna, Ádám…[et al.]. Rapidly Progressing Refractory Hodgkin Lymphoma: A Case Report and a Possible Explanation. Case Reports in Medicine No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1101159
American Medical Association (AMA)
Jóna, Ádám& Irsai, Gábor& Barna, Sándor& Méhes, Gábor& Illés, Árpád& Váróczy, László. Rapidly Progressing Refractory Hodgkin Lymphoma: A Case Report and a Possible Explanation. Case Reports in Medicine. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101159