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Podocyturia: A Clue for the Rational Use of Amiloride in Alport Renal Disease
Joint Authors
Trimarchi, Hernán
Pomeranz, Vanesa
Iriarte, Romina
Forrester, Mariano
Canzonieri, R.
Muryan, A.
Andrews, J.
Rengel, T.
Schiel, A.
Araoz, A.
Paulero, M.
Zotta, Elsa
Lombi, Fernando
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-28
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
No specific or efficient treatment exists for Alport syndrome, an X-linked hereditary disease caused by mutations in collagen type IV, a crucial component of the glomerular basement membrane.
Kidney failure is usually a major complication of the disease, and patients require renal replacement therapy early in life.
Microhematuria and subsequently proteinuria are hallmarks of kidney involvement, which are due to primary basement membrane alterations that mainly cause endothelial thrombosis and podocyte contraction and ulterior irreversible detachment.
Commonly drug-based approaches include angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, which are employed to reduce proteinuria and thus retard kidney disease progression and cardiovascular morbidity and mortality.
However, as any hereditary disease, it is expressed as early as in the intrauterine life, and usually an index case is helpful to detect family-related cases.
As no specific treatment exists, pathophysiologically based approaches are useful.
The present case illustrates the reduction rate of urinary podocyte loss and proteinuria after amiloride administration and suggests the molecular pathways involved in Alport renal disease.
Finally, podocyturia rather than proteinuria should be considered as an earlier biomarker of kidney involvement and disease progression in Alport disease.
American Psychological Association (APA)
Trimarchi, Hernán& Canzonieri, R.& Muryan, A.& Schiel, A.& Araoz, A.& Paulero, M.…[et al.]. 2016. Podocyturia: A Clue for the Rational Use of Amiloride in Alport Renal Disease. Case Reports in Nephrology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101208
Modern Language Association (MLA)
Trimarchi, Hernán…[et al.]. Podocyturia: A Clue for the Rational Use of Amiloride in Alport Renal Disease. Case Reports in Nephrology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1101208
American Medical Association (AMA)
Trimarchi, Hernán& Canzonieri, R.& Muryan, A.& Schiel, A.& Araoz, A.& Paulero, M.…[et al.]. Podocyturia: A Clue for the Rational Use of Amiloride in Alport Renal Disease. Case Reports in Nephrology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101208