Drug-Induced Acute Interstitial Nephritis with Nifedipine
Joint Authors
Golbin, Léonard
Dolley-Hitze, Thibault
Lorcy, Nolwenn
Vigneau, Cécile
Rioux-Leclercq, Nathalie
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-03
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
Acute interstitial nephritis (AIN) is a frequent cause of Acute Kidney Injury (AKI).
Drug hypersensitivity is the most common etiology and the list of drugs that can induce AIN is not exhaustive yet.
Case Report.
Here, we describe the case of a 43-year-old man who was treated with nifedipine (Adalate®) for Raynaud’s syndrome.
After nifedipine introduction, serum creatininemia progressively increased from 91 to 188 μmol/L in a few months and AKI was diagnosed.
Laboratory work-up results indicated the presence of tubular proteinuria and nonspecific inflammatory syndrome.
Histological analysis found granulomatous interstitial nephropathy without necrosis in 20% of the kidney biopsy without immunofluorescent deposit.
Nifedipine was stopped and corticosteroid treatment was started with a rapid but incomplete reduction of serum creatininemia level to 106 μmol/L.
Conclusion.
This is the first case of AIN caused by nifedipine.
American Psychological Association (APA)
Golbin, Léonard& Dolley-Hitze, Thibault& Lorcy, Nolwenn& Rioux-Leclercq, Nathalie& Vigneau, Cécile. 2016. Drug-Induced Acute Interstitial Nephritis with Nifedipine. Case Reports in Nephrology،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1101209
Modern Language Association (MLA)
Golbin, Léonard…[et al.]. Drug-Induced Acute Interstitial Nephritis with Nifedipine. Case Reports in Nephrology No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1101209
American Medical Association (AMA)
Golbin, Léonard& Dolley-Hitze, Thibault& Lorcy, Nolwenn& Rioux-Leclercq, Nathalie& Vigneau, Cécile. Drug-Induced Acute Interstitial Nephritis with Nifedipine. Case Reports in Nephrology. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1101209
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101209