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Ganciclovir-Resistant Cytomegalovirus Infection in a Kidney Transplant Recipient Successfully Treated with Foscarnet and Everolimus
Joint Authors
Lazzarotto, Tiziana
Baraldi, Olga
Comai, Giorgia
La Manna, Gaetano
Menghi, Viola
Liviano D’Arcangelo, Giovanni
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-31
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Cytomegalovirus (CMV) infection remains a major cause of morbidity, graft failure, and death in kidney transplant recipients.
We describe a case of a 53-year-old CMV-seronegative man who underwent renal transplant from a CMV-positive donor and who developed ganciclovir- (GCV-) resistant CMV infection.
Foscarnet was started while immunosuppressive therapy was modified with the introduction of everolimus minimizing tacrolimus dosage.
Only two weeks after the start of this treatment regimen was the patient’s viral load negative.
At two-year follow-up the patient has no clinical or laboratory signs of CMV infection and a good and stable renal function or graft survival.
In our case, administration of an mTOR inhibitor combined with foscarnet led to rapid and persistent viral clearance without compromising short- and medium-term graft function.
This combination therapy supports the need for the kidney transplant community to individualize a target therapy for each type of GCV-resistant CMV infection.
American Psychological Association (APA)
Menghi, Viola& Comai, Giorgia& Baraldi, Olga& Liviano D’Arcangelo, Giovanni& Lazzarotto, Tiziana& La Manna, Gaetano. 2016. Ganciclovir-Resistant Cytomegalovirus Infection in a Kidney Transplant Recipient Successfully Treated with Foscarnet and Everolimus. Case Reports in Nephrology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101213
Modern Language Association (MLA)
Menghi, Viola…[et al.]. Ganciclovir-Resistant Cytomegalovirus Infection in a Kidney Transplant Recipient Successfully Treated with Foscarnet and Everolimus. Case Reports in Nephrology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1101213
American Medical Association (AMA)
Menghi, Viola& Comai, Giorgia& Baraldi, Olga& Liviano D’Arcangelo, Giovanni& Lazzarotto, Tiziana& La Manna, Gaetano. Ganciclovir-Resistant Cytomegalovirus Infection in a Kidney Transplant Recipient Successfully Treated with Foscarnet and Everolimus. Case Reports in Nephrology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101213