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Adjustment of Eculizumab Dosage Pattern in Patients with Atypical Hemolytic Uremic Syndrome with Suboptimal Response to Standard Treatment Pattern
Joint Authors
Quiroga, Borja
García Monteavaro, Camino
Peralta Roselló, Carmen
Baltar Martín, José María
Castillo Eraso, Lorena
de Álvaro Moreno, Fernando
Martínez Vea, Alberto
Visus-Fernández de Manzanos, María Teresa
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In patients with atypical hemolytic uremic syndrome (aHUS), complement blocking by eculizumab rapidly halts the process of thrombotic microangiopathy and it is associated with clear long-term hematologic and renal improvements.
Eculizumab treatment consists of a 4-week initial phase with weekly IV administration of 900 mg doses, followed by a maintenance phase with a 1,200 mg dose in the fifth week and every 14±2 days thereafter.
We present three patients with aHUS and suboptimal response to eculizumab treatment at the usual administration dosage who showed hematologic and renal improvements after an adjustment in the eculizumab treatment protocol.
American Psychological Association (APA)
García Monteavaro, Camino& Peralta Roselló, Carmen& Quiroga, Borja& Baltar Martín, José María& Castillo Eraso, Lorena& de Álvaro Moreno, Fernando…[et al.]. 2016. Adjustment of Eculizumab Dosage Pattern in Patients with Atypical Hemolytic Uremic Syndrome with Suboptimal Response to Standard Treatment Pattern. Case Reports in Nephrology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1101230
Modern Language Association (MLA)
García Monteavaro, Camino…[et al.]. Adjustment of Eculizumab Dosage Pattern in Patients with Atypical Hemolytic Uremic Syndrome with Suboptimal Response to Standard Treatment Pattern. Case Reports in Nephrology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1101230
American Medical Association (AMA)
García Monteavaro, Camino& Peralta Roselló, Carmen& Quiroga, Borja& Baltar Martín, José María& Castillo Eraso, Lorena& de Álvaro Moreno, Fernando…[et al.]. Adjustment of Eculizumab Dosage Pattern in Patients with Atypical Hemolytic Uremic Syndrome with Suboptimal Response to Standard Treatment Pattern. Case Reports in Nephrology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1101230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101230