Small-Cell Lung Cancer with Positive Anti-NMDAR and Anti-AMPAR Antibodies Paraneoplastic Limbic Encephalitis
Joint Authors
Boangher, Sabina
Mespouille, Pascal
Filip, Corina-Mihaela
Goffette, Sophie
Source
Case Reports in Neurological Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-13
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
We report the case of a 66-year-old woman, with paraneoplastic limbic encephalitis, treated 6 months earlier for bladder neoplasia.
The patient presented to the emergency room with rapidly increasing symptoms, noninfectious cerebral spinal fluid associated with positive anti-NMDAR (as well as in serum) and positive AMPAR antibodies in the serum.
Four months later, the patient was diagnosed with a small-cell lung cancer for which chemotherapy and radiotherapy was commenced.
Simultaneously, endoscopic surgical treatment was undertaken for an in situ relapse of the bladder neoplasm.
After the completion of 3 cycles of chemotherapy her neurological status temporarily worsened.
The cerebral MRI did not show signs of encephalitis such as increased T2/FLAIR signal intensity in the mesial temporal lobes and limbic systems.
No specific treatment was prescribed.
Limbic encephalitis can be associated with malignant tumors such as lung carcinoma.
Several cases reported in the literature have shown cognitive improvement after tumoral therapy.
Regarding our experience, significant progress was achieved through immuno-modulatory treatment.
A transitory deterioration of the cognitive process was perceived during the chemotherapy sessions.
American Psychological Association (APA)
Boangher, Sabina& Mespouille, Pascal& Filip, Corina-Mihaela& Goffette, Sophie. 2016. Small-Cell Lung Cancer with Positive Anti-NMDAR and Anti-AMPAR Antibodies Paraneoplastic Limbic Encephalitis. Case Reports in Neurological Medicine،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1101257
Modern Language Association (MLA)
Boangher, Sabina…[et al.]. Small-Cell Lung Cancer with Positive Anti-NMDAR and Anti-AMPAR Antibodies Paraneoplastic Limbic Encephalitis. Case Reports in Neurological Medicine No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1101257
American Medical Association (AMA)
Boangher, Sabina& Mespouille, Pascal& Filip, Corina-Mihaela& Goffette, Sophie. Small-Cell Lung Cancer with Positive Anti-NMDAR and Anti-AMPAR Antibodies Paraneoplastic Limbic Encephalitis. Case Reports in Neurological Medicine. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1101257
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101257