Miller-Fisher Syndrome: Are Anti-GAD Antibodies Implicated in Its Pathophysiology?
Joint Authors
Dagklis, Ioannis E.
Papagiannopoulos, Sotirios
Theodoridou, Varvara
Argyropoulou, Ourania
Bostantjopoulou, Sevasti
Kazis, Dimitrios
Source
Case Reports in Neurological Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-30
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Miller-Fisher syndrome (MFS) is considered as a variant of the Guillain-Barre syndrome (GBS) and its characteristic clinical features are ophthalmoplegia, ataxia, and areflexia.
Typically, it is associated with anti-GQ1b antibodies; however, a significant percentage (>10%) of these patients are seronegative.
Here, we report a 67-year-old female patient who presented with the typical clinical features of MFS.
Workup revealed antibodies against glutamic acid decarboxylase (GAD) in relatively high titers while GQ1b antibodies were negative.
Neurological improvement was observed after intravenous gamma globulin and follow-up examinations showed a continuous clinical amelioration with simultaneous decline of anti-GAD levels which finally returned to normal values.
This case indicates that anti-GAD antibodies may be associated with a broader clinical spectrum and future studies in GQ1b-seronegative patients could determine ultimately their clinical and pathogenetic significance in this syndrome.
American Psychological Association (APA)
Dagklis, Ioannis E.& Papagiannopoulos, Sotirios& Theodoridou, Varvara& Kazis, Dimitrios& Argyropoulou, Ourania& Bostantjopoulou, Sevasti. 2016. Miller-Fisher Syndrome: Are Anti-GAD Antibodies Implicated in Its Pathophysiology?. Case Reports in Neurological Medicine،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1101262
Modern Language Association (MLA)
Dagklis, Ioannis E.…[et al.]. Miller-Fisher Syndrome: Are Anti-GAD Antibodies Implicated in Its Pathophysiology?. Case Reports in Neurological Medicine No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1101262
American Medical Association (AMA)
Dagklis, Ioannis E.& Papagiannopoulos, Sotirios& Theodoridou, Varvara& Kazis, Dimitrios& Argyropoulou, Ourania& Bostantjopoulou, Sevasti. Miller-Fisher Syndrome: Are Anti-GAD Antibodies Implicated in Its Pathophysiology?. Case Reports in Neurological Medicine. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1101262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101262