Proximal Limb Weakness in a Patient with Celiac Disease: Copper Deficiency, Gluten Sensitivity, or Both as the Underlying Cause?
Joint Authors
Source
Case Reports in Neurological Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Celiac disease has been associated with several neurologic disorders which may result from micronutrient deficiencies, coexisting autoimmune conditions, or gluten sensitivity.
Copper deficiency can produce multiple neurologic manifestations.
Myeloneuropathy is the most common neurologic syndrome and it is often irreversible, despite copper replacement.
We report the case of a 55-year-old man who presented with progressive proximal limb weakness and weight loss in the setting of untreated celiac disease without gastrointestinal symptoms.
He had anemia, neutropenia, and severe hypocupremia.
The pattern of weakness raised the suspicion that there was an underlying myopathy, although this was not confirmed by electrodiagnostic studies.
Weakness and hematologic abnormalities resolved completely within 1 month of total parenteral nutrition with copper supplementation and a gluten-free diet.
Myopathy can rarely occur in patients with celiac disease, but the mechanism is unclear.
Pure proximal limb weakness has not been previously reported in copper deficiency.
We propose that this may represent a novel manifestation of hypocupremia and recommend considering copper deficiency and gluten sensitivity in patients presenting with proximal limb weakness.
American Psychological Association (APA)
Avila, J. David& Lacomis, David. 2016. Proximal Limb Weakness in a Patient with Celiac Disease: Copper Deficiency, Gluten Sensitivity, or Both as the Underlying Cause?. Case Reports in Neurological Medicine،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101295
Modern Language Association (MLA)
Avila, J. David& Lacomis, David. Proximal Limb Weakness in a Patient with Celiac Disease: Copper Deficiency, Gluten Sensitivity, or Both as the Underlying Cause?. Case Reports in Neurological Medicine No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1101295
American Medical Association (AMA)
Avila, J. David& Lacomis, David. Proximal Limb Weakness in a Patient with Celiac Disease: Copper Deficiency, Gluten Sensitivity, or Both as the Underlying Cause?. Case Reports in Neurological Medicine. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101295