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Progressive Multifocal Leukoencephalopathy in a Multiple Sclerosis Patient Diagnosed after Switching from Natalizumab to Fingolimod
Joint Authors
Sinnecker, Tim
Othman, Jalal
Kühl, Marc
Metz, Imke
Niendorf, Thoralf
Kunkel, Annett
Wuerfel, Jens
Faiss, Juergen
Paul, Friedemann
Source
Case Reports in Neurological Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Natalizumab- (NTZ-) associated progressive multifocal leukoencephalopathy (PML) is a severe and often disabling infectious central nervous system disease that can become evident in multiple sclerosis (MS) patients after NTZ discontinuation.
Recently, novel diagnostic biomarkers for the assessment of PML risk in NTZ treated MS patients such as the anti-JC virus antibody index have been reported, and the clinical relevance of milky-way lesions detectable by MRI has been discussed.
Case Presentation and Conclusion.
We report a MS patient in whom PML was highly suspected solely based on MRI findings after switching from NTZ to fingolimod despite repeatedly negative (ultrasensitive) polymerase chain reaction (PCR) testing for JC virus DNA in cerebrospinal fluid.
The PML diagnosis was histopathologically confirmed by brain biopsy.
The occurrence of an immune reconstitution inflammatory syndrome (IRIS) during fingolimod therapy, elevated measures of JCV antibody indices, and the relevance of milky-way-like lesions detectable by (7 T) MRI are discussed.
American Psychological Association (APA)
Sinnecker, Tim& Othman, Jalal& Kühl, Marc& Metz, Imke& Niendorf, Thoralf& Kunkel, Annett…[et al.]. 2016. Progressive Multifocal Leukoencephalopathy in a Multiple Sclerosis Patient Diagnosed after Switching from Natalizumab to Fingolimod. Case Reports in Neurological Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1101302
Modern Language Association (MLA)
Sinnecker, Tim…[et al.]. Progressive Multifocal Leukoencephalopathy in a Multiple Sclerosis Patient Diagnosed after Switching from Natalizumab to Fingolimod. Case Reports in Neurological Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1101302
American Medical Association (AMA)
Sinnecker, Tim& Othman, Jalal& Kühl, Marc& Metz, Imke& Niendorf, Thoralf& Kunkel, Annett…[et al.]. Progressive Multifocal Leukoencephalopathy in a Multiple Sclerosis Patient Diagnosed after Switching from Natalizumab to Fingolimod. Case Reports in Neurological Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1101302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101302