Intrahepatic Cholestasis of Pregnancy with Severe Elevation of Bile Acids in the Setting of Acute Hepatitis C Infection
Joint Authors
Lawlor, Megan L.
Critchfield, Agatha S.
Source
Case Reports in Obstetrics and Gynecology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-06
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Intrahepatic cholestasis of pregnancy (ICP) is a complication of pregnancy resulting in elevation of serum bile acid levels.
ICP is often associated with underlying liver disease, including hepatitis C.
Bile acids in relationship to the acute infection of hepatitis C virus have not yet been delineated in the literature.
A 26-year-old gravida 4 para 2103 with dichorionic, diamniotic twin gestation and history of intravenous drug abuse developed ICP in the setting of acute hepatitis C infection.
In addition to clinical symptoms of pruritus and right upper quadrant pain, she developed severe elevation in bile acids, 239 micromol/L, and transaminitis aspartate aminotransferase 1033 U/L, and alanine aminotransferase 448 U/L.
She received ursodeoxycholic acid and antenatal testing was performed.
Patient delivered vaginally at 33-week gestation following preterm rupture of membranes.
Neonates were admitted to NICU and had uncomplicated neonatal courses.
In the setting of ICP with significant transaminitis and severe elevation of bile acids, consideration of acute viral hepatitis is important, especially considering the worsening opioid epidemic and concurrent increase in intravenous drug use in the United States.
Further study is needed regarding the acute form of HCV infection and its effect on ICP and associated bile acids.
American Psychological Association (APA)
Lawlor, Megan L.& Critchfield, Agatha S.. 2016. Intrahepatic Cholestasis of Pregnancy with Severe Elevation of Bile Acids in the Setting of Acute Hepatitis C Infection. Case Reports in Obstetrics and Gynecology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101542
Modern Language Association (MLA)
Lawlor, Megan L.& Critchfield, Agatha S.. Intrahepatic Cholestasis of Pregnancy with Severe Elevation of Bile Acids in the Setting of Acute Hepatitis C Infection. Case Reports in Obstetrics and Gynecology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1101542
American Medical Association (AMA)
Lawlor, Megan L.& Critchfield, Agatha S.. Intrahepatic Cholestasis of Pregnancy with Severe Elevation of Bile Acids in the Setting of Acute Hepatitis C Infection. Case Reports in Obstetrics and Gynecology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101542