A Case of Non-Small Cell Lung Cancer with Possible “Disease Flare” on Nivolumab Treatment
Joint Authors
Chubachi, Shotaro
Yasuda, Hiroyuki
Irie, Hidehiro
Fukunaga, Koichi
Naoki, Katsuhiko
Soejima, Kenzo
Betsuyaku, Tomoko
Source
Case Reports in Oncological Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-27
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
Recent clinical trials proven the clinically significant efficacy and tolerability of nivolumab, a programmed death 1 (PD-1) inhibitor, in previously treated patients with non-small cell lung cancer (NSCLC).
Case Presentation.
Here, we describe the case of a patient who experienced possible “disease flare” immediately after initiation of nivolumab treatment.
A 54-year-old man was diagnosed with Stage IIB (T2N1M0) lung adenocarcinoma.
After 7 years from recurrence, 10th line chemotherapy, nivolumab, was initiated.
Six weeks later, after 3 cycles of nivolumab treatment, rapid lung cancer progression was observed with an increase in the size of the primary lesion, multiple novel nodules on both lungs, and multiple novel brain metastases.
Conclusion.
We believe that physicians should be made aware that, in a subset of NSCLC patients, disease flare might occur on nivolumab treatment.
American Psychological Association (APA)
Chubachi, Shotaro& Yasuda, Hiroyuki& Irie, Hidehiro& Fukunaga, Koichi& Naoki, Katsuhiko& Soejima, Kenzo…[et al.]. 2016. A Case of Non-Small Cell Lung Cancer with Possible “Disease Flare” on Nivolumab Treatment. Case Reports in Oncological Medicine،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1101641
Modern Language Association (MLA)
Chubachi, Shotaro…[et al.]. A Case of Non-Small Cell Lung Cancer with Possible “Disease Flare” on Nivolumab Treatment. Case Reports in Oncological Medicine No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1101641
American Medical Association (AMA)
Chubachi, Shotaro& Yasuda, Hiroyuki& Irie, Hidehiro& Fukunaga, Koichi& Naoki, Katsuhiko& Soejima, Kenzo…[et al.]. A Case of Non-Small Cell Lung Cancer with Possible “Disease Flare” on Nivolumab Treatment. Case Reports in Oncological Medicine. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1101641
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101641