Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on Management
Joint Authors
Babu, Govind
Babu, Suresh
Lokesh, K. N.
Bhat, Gita R.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Acute promyelocytic leukemia is characterized by t(15;17).
This leads to the formation of PML/RARα which blocks the differentiation of blasts at the stage of promyelocytes.
This is reversed by all-trans-retinoic acid (ATRA), a vitamin A derivative.
Acute myocardial ischemia is a rare side effect of ATRA.
Case Report.
We report a case of acute coronary syndrome manifesting as an adverse effect of ATRA in a lady with APL who had no other risk factors for cardiovascular disease.
Conclusions.
We emphasize the need for high index of suspicion for the diagnosis of this entity.
In the light of this case, the rare instances of ATRA associated acute myocardial ischemia recorded in the literature and the options available for treatment of acute promyelocytic leukemia sans ATRA have been reviewed.
American Psychological Association (APA)
Babu, Govind& Lokesh, K. N.& Babu, Suresh& Bhat, Gita R.. 2016. Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on Management. Case Reports in Oncological Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1101666
Modern Language Association (MLA)
Babu, Govind…[et al.]. Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on Management. Case Reports in Oncological Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1101666
American Medical Association (AMA)
Babu, Govind& Lokesh, K. N.& Babu, Suresh& Bhat, Gita R.. Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on Management. Case Reports in Oncological Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1101666
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101666