Durable Clinical Benefit of Pertuzumab in a Young Patient with BRCA2 Mutation and HER2-Overexpressing Breast Cancer Involving the Brain
Joint Authors
Koumarianou, Anna
Kontopoulou, Christina
Tsionou, Christina
Kouloulias, Vassilis
Source
Case Reports in Oncological Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Patients with HER2-positive breast cancer and brain metastases have limited treatment options, and, as a result of their poor performance status and worse prognosis, they are underrepresented in clinical trials.
Not surprisingly, these patients may not be fit enough to receive any active treatment and are offered supportive therapy.
BRCA2 mutations are reported to be rarely associated with HER2-overexpressing advanced breast cancer and even more rarely with brain metastases at diagnosis.
We report on a BRCA2-positive breast cancer patient with metastatic disease in multiple sites, including the brain, and poor performance status who exhibited an extraordinary clinical and imaging response to the novel anti-HER2 therapy pertuzumab after multiple lines of therapy including anti-HER2 targeting.
To our knowledge, the clinicopathologic and therapeutic characteristics of this patient point to a unique case and an urgent need for further investigation of pertuzumab in patients with brain metastases.
American Psychological Association (APA)
Koumarianou, Anna& Kontopoulou, Christina& Kouloulias, Vassilis& Tsionou, Christina. 2016. Durable Clinical Benefit of Pertuzumab in a Young Patient with BRCA2 Mutation and HER2-Overexpressing Breast Cancer Involving the Brain. Case Reports in Oncological Medicine،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1101700
Modern Language Association (MLA)
Koumarianou, Anna…[et al.]. Durable Clinical Benefit of Pertuzumab in a Young Patient with BRCA2 Mutation and HER2-Overexpressing Breast Cancer Involving the Brain. Case Reports in Oncological Medicine No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1101700
American Medical Association (AMA)
Koumarianou, Anna& Kontopoulou, Christina& Kouloulias, Vassilis& Tsionou, Christina. Durable Clinical Benefit of Pertuzumab in a Young Patient with BRCA2 Mutation and HER2-Overexpressing Breast Cancer Involving the Brain. Case Reports in Oncological Medicine. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1101700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101700