Pulmonary Fibrosis after Pegylated Liposomal Doxorubicin in Elderly Patient with Cutaneous Angiosarcoma
Joint Authors
Mazzotta, Marco
Giusti, Raffaele
Iacono, Daniela
Lauro, Salvatore
Marchetti, Paolo
Source
Case Reports in Oncological Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Angiosarcoma is a rare cancer of the inner lining of blood vessels and can arise anywhere in the body, most commonly presenting as cutaneous disease in elderly patient, involving head and neck (H&N), especially the scalp.
Pegylated liposomal doxorubicin (PLD) is one of the available treatments in patients with advanced or metastatic disease.
Common toxicities are myelosuppression, palmar-plantar erythrodysesthesia, nausea, and stomatitis.
Regarding PLD-related pulmonary fibrosis in an uncommon toxicity, there are few cases reported in literature.
None of these occurred in angiosarcoma.
Methods.
This is a case report describing an elderly patient treated with PLD for advanced H&N cutaneous angiosarcoma who developed G5 pulmonary toxicity after the second PLD administration.
Results.
According to our data and patient clinical outcome, we believe that she passed away from fatal PLD-induced pulmonary fibrosis.
This is the first case of fatal interstitial pneumonitis in a 77-year-old woman treated with PLD for angiosarcoma.
The case has been reported for its rarity.
Conclusions.
Pathophysiology of this phenomenon is still unclear and more studies are necessary to understand the true incidence of pulmonary toxicities in patients in treatments with PLD and its mechanism.
American Psychological Association (APA)
Mazzotta, Marco& Giusti, Raffaele& Iacono, Daniela& Lauro, Salvatore& Marchetti, Paolo. 2016. Pulmonary Fibrosis after Pegylated Liposomal Doxorubicin in Elderly Patient with Cutaneous Angiosarcoma. Case Reports in Oncological Medicine،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1101718
Modern Language Association (MLA)
Mazzotta, Marco…[et al.]. Pulmonary Fibrosis after Pegylated Liposomal Doxorubicin in Elderly Patient with Cutaneous Angiosarcoma. Case Reports in Oncological Medicine No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1101718
American Medical Association (AMA)
Mazzotta, Marco& Giusti, Raffaele& Iacono, Daniela& Lauro, Salvatore& Marchetti, Paolo. Pulmonary Fibrosis after Pegylated Liposomal Doxorubicin in Elderly Patient with Cutaneous Angiosarcoma. Case Reports in Oncological Medicine. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1101718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101718