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Two Cases of Heavy Chain MGUS
Joint Authors
Van Keer, Jan
Meijers, Björn
Delforge, Michel
Verhoef, Gregor
Poesen, Koen
Source
Case Reports in Oncological Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Heavy chain diseases are rare variants of B-cell lymphomas that produce one of three classes of immunoglobulin heavy chains, without corresponding light chains.
We describe two patients with asymptomatic heavy chain monoclonal gammopathy.
The first patient is a 51-year-old woman with alpha paraprotein on serum immunofixation.
The second case is a 46-year-old woman with gamma paraprotein on urine immunofixation.
Neither patient had corresponding monoclonal light chains.
Workup for multiple myeloma and lymphoma was negative in both patients.
These two cases illustrate that heavy chain monoclonal gammopathy can exist in the absence of clinically apparent malignancy.
Only a few reports of “heavy chain MGUS” have been described before.
In the absence of specialized guidelines, we suggest a similar follow-up as for MGUS, while taking into account the higher probability of progression to lymphoma than to myeloma.
American Psychological Association (APA)
Van Keer, Jan& Meijers, Björn& Delforge, Michel& Verhoef, Gregor& Poesen, Koen. 2016. Two Cases of Heavy Chain MGUS. Case Reports in Oncological Medicine،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101728
Modern Language Association (MLA)
Van Keer, Jan…[et al.]. Two Cases of Heavy Chain MGUS. Case Reports in Oncological Medicine No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1101728
American Medical Association (AMA)
Van Keer, Jan& Meijers, Björn& Delforge, Michel& Verhoef, Gregor& Poesen, Koen. Two Cases of Heavy Chain MGUS. Case Reports in Oncological Medicine. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101728