Nodular Scleritis Associated with Herpes Zoster Virus: An Infectious and Immune-Mediated Process
Joint Authors
Loureiro, Mónica
Rothwell, Renata
Fonseca, Sofia
Source
Case Reports in Ophthalmological Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-19
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Purpose.
To describe a case of anterior nodular scleritis, preceded by an anterior hypertensive uveitis, which was primarily caused by varicella zoster virus (VZV).
Case Report.
A 54-year-old woman presented with anterior uveitis of the right eye presumably caused by herpetic viral disease and was successfully treated.
Two months later, she developed a nodular scleritis and started oral nonsteroidal anti-inflammatory without effect.
A complete laboratory workup revealed positivity for HLA-B27; the infectious workup was negative.
Therapy was changed to oral prednisolone and an incomplete improvement occurred.
Therefore, a diagnostic anterior paracentesis was performed and the polymerase chain reaction (PCR) analysis revealed VZV.
She was treated with valacyclovir and the oral prednisolone began to decrease; however, a marked worsening of the scleritis occurred with the reduction of the daily dose; subsequently, methotrexate was introduced allowing the suspension of the prednisolone and led to clinical resolution of the scleritis.
Conclusion.
This report of anterior nodular scleritis caused by VZV argues in favor of an underlying immune-mediated component, requiring immunosuppressive therapy for clinical resolution.
The PCR analysis of the aqueous humor was revealed to be a valuable technique and should be considered in cases of scleritis with poor response to treatment.
American Psychological Association (APA)
Loureiro, Mónica& Rothwell, Renata& Fonseca, Sofia. 2016. Nodular Scleritis Associated with Herpes Zoster Virus: An Infectious and Immune-Mediated Process. Case Reports in Ophthalmological Medicine،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1101853
Modern Language Association (MLA)
Loureiro, Mónica…[et al.]. Nodular Scleritis Associated with Herpes Zoster Virus: An Infectious and Immune-Mediated Process. Case Reports in Ophthalmological Medicine No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1101853
American Medical Association (AMA)
Loureiro, Mónica& Rothwell, Renata& Fonseca, Sofia. Nodular Scleritis Associated with Herpes Zoster Virus: An Infectious and Immune-Mediated Process. Case Reports in Ophthalmological Medicine. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1101853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101853