Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review

Abstract EN

Adult extrarenal nephroblastoma is a very rare tumor.

Nephroblastoma arising from primary testicular germ cell tumor is exceedingly rare.

To our knowledge, only three cases have been reported in the English literature.

We report a case of a 19-year-old man who presented with a large right testicle.

Image studies showed a large retroperitoneal mass along with liver and lung metastases.

Orchiectomy demonstrated a mixed germ cell tumor composed of yolk sac tumor, embryonal carcinoma, and mature and immature teratoma with a significant portion of nephroblastoma.

The patient received chemotherapy and no recurrence was noted during six months of followup.

WT-1 expression was also studied due to the lack of consistency of its expression in testicular nephroblastoma in the literature.

We also present a discussion and review of the literature due to its rarity, which indicate an adverse prognosis for patients with nephroblastoma components receiving standard chemotherapeutical regimes for testicular germ cell tumors.