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A Fatal Case of Congenital Langerhans Cell Histiocytosis with Disseminated Cutaneous Lesions in a Premature Neonate
Joint Authors
Inoue, Michio
Tomita, Yoko
Egawa, Tsuyoshi
Ioroi, Tomoaki
Kugo, Masaaki
Imashuku, Shinsaku
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-19
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
The outcome of neonates with congenital cutaneous Langerhans cell histiocytosis (LCH) is variable.
Observations.
We report a case of LCH in a female premature neonate born at 33-week gestation.
She had disseminated cutaneous lesions, which consisted of hemorrhagic papules and vesicles, with sparse healthy skin areas, and the hands and feet were contracted with scarring and blackened.
She was in respiratory failure although no apparent pulmonary or bone lesions on X-rays were noted.
Skin biopsy confirmed a diagnosis of LCH due to observation of CD1a+ Langerhans cells, which lacked expression of E-cadherin and CD56.
The patient died 57 hours after birth.
Conclusions.
Based on this case and the literature survey, the outcome of premature babies with congenital cutaneous LCH lesions is noted to be unfavorable, with the majority of such cases suffering from multisystem disease.
American Psychological Association (APA)
Inoue, Michio& Tomita, Yoko& Egawa, Tsuyoshi& Ioroi, Tomoaki& Kugo, Masaaki& Imashuku, Shinsaku. 2016. A Fatal Case of Congenital Langerhans Cell Histiocytosis with Disseminated Cutaneous Lesions in a Premature Neonate. Case Reports in Pediatrics،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1102408
Modern Language Association (MLA)
Inoue, Michio…[et al.]. A Fatal Case of Congenital Langerhans Cell Histiocytosis with Disseminated Cutaneous Lesions in a Premature Neonate. Case Reports in Pediatrics No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1102408
American Medical Association (AMA)
Inoue, Michio& Tomita, Yoko& Egawa, Tsuyoshi& Ioroi, Tomoaki& Kugo, Masaaki& Imashuku, Shinsaku. A Fatal Case of Congenital Langerhans Cell Histiocytosis with Disseminated Cutaneous Lesions in a Premature Neonate. Case Reports in Pediatrics. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1102408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1102408