Development of Tinnitus at a Low Dose of Sertraline: Clinical Course and Proposed Mechanisms
Author
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-15
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Introduction.
Serotonin is involved in filtering of auditory stimuli.
Cochlear input is processed through complex interactions between serotonergic, glutamatergic, and GABAergic neurotransmitter systems.
Options for treatment of tinnitus include selective serotonin reuptake inhibitors (SSRIs); however in rare instances this symptom may occur as a side effect of this class of medications.
Case Presentation.
A 50-year-old woman developed bilateral tinnitus after several weeks of being treated with sertraline 50 mg.
She had been on a long-standing daily dose of aspirin 325 mg which had been discontinued shortly before starting sertraline.
Medical work-up was negative for her symptom.
Shortly after discontinuation of the medication, her tinnitus subsided completely.
Discussion.
Tinnitus is a rare side effect of sertraline and may be related to particular distribution of serotonin receptor subtypes within the auditory system, and serotonergic agents may reinforce or desensitize the activity of different receptors.
Also, there may be a priming effect of salicylate agents on the auditory system, predisposing particular patients to be more sensitive to how auditory stimuli are processed.
American Psychological Association (APA)
Miller, Christopher W. T.. 2016. Development of Tinnitus at a Low Dose of Sertraline: Clinical Course and Proposed Mechanisms. Case Reports in Psychiatry،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1102479
Modern Language Association (MLA)
Miller, Christopher W. T.. Development of Tinnitus at a Low Dose of Sertraline: Clinical Course and Proposed Mechanisms. Case Reports in Psychiatry No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1102479
American Medical Association (AMA)
Miller, Christopher W. T.. Development of Tinnitus at a Low Dose of Sertraline: Clinical Course and Proposed Mechanisms. Case Reports in Psychiatry. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1102479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1102479