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A Rare Case of Mixed Neuroendocrine Tumor and Adenocarcinoma of the Pancreas
Joint Authors
Tzardi, Maria
Xenaki, S.
Chrysos, E.
Lasithiotakis, Konstantinos
Andreou, Alexandros
Aggelaki, Sofia
Chalkiadakis, George
Daskalaki, Anna
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Introduction.
Neuroendocrine carcinoma (NEC) of pancreas is a rare tumor with aggressive progression and poor prognosis.
Its coexistence with adenocarcinoma poses significant clinical problems and has not been addressed in the literature.
Methods.
We describe a case of a 51-year-old male who underwent pancreatoduodenectomy due to pancreatic head tumor 1.5 × 1 × 1.4 cm.
Histological examination of the specimen revealed a mixed neoplasm: (1) a well differentiated adenocarcinoma, neoplastic blasts of which are extended focally to the submucosa without invading the muscular layer, and (2) a low differentiated NEC consisting of solid clusters and pagetoid formations.
All 18 lymph nodes of the specimen were free of neoplastic disease and the surgical margins of the specimen were tumor-free.
No adjuvant treatment was administered and two months after the operation the patient developed liver metastasis.
FNA cytology of the hepatic lesions revealed low grade carcinoma with neuroendocrine characteristics.
Five lines of chemotherapy were administered: VP + CDDP, paclitaxel + ifosfamide + Mesna + CDDP, Folfox + Avastin, Folfiri + Avastin, and CAV.
During his treatment he revealed PD and succumbed to his disease 13 months after the operation.
Conclusion.
Coexistence of NEC with adenocarcinoma of the pancreas is a very rare entity presenting significant challenges regarding its adjuvant treatment and the treatment of distant relapse.
American Psychological Association (APA)
Xenaki, S.& Lasithiotakis, Konstantinos& Andreou, Alexandros& Aggelaki, Sofia& Tzardi, Maria& Daskalaki, Anna…[et al.]. 2016. A Rare Case of Mixed Neuroendocrine Tumor and Adenocarcinoma of the Pancreas. Case Reports in Surgery،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1102734
Modern Language Association (MLA)
Xenaki, S.…[et al.]. A Rare Case of Mixed Neuroendocrine Tumor and Adenocarcinoma of the Pancreas. Case Reports in Surgery No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1102734
American Medical Association (AMA)
Xenaki, S.& Lasithiotakis, Konstantinos& Andreou, Alexandros& Aggelaki, Sofia& Tzardi, Maria& Daskalaki, Anna…[et al.]. A Rare Case of Mixed Neuroendocrine Tumor and Adenocarcinoma of the Pancreas. Case Reports in Surgery. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1102734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1102734