False Positive B-Cells Crossmatch after Prior Rituximab Exposure of the Kidney Donor
Joint Authors
Desoutter, Judith
Apithy, Marie-Joëlle
Bartczak, Ségolène
Guillaume, Nicolas
Source
Case Reports in Transplantation
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-28
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Crossmatching is essential prior to kidney transplantation to confirm compatibility between the donor and the recipient, particularly to prevent acute antibody-mediated rejection.
An unexpected positive crossmatch may be obtained in recipients with an autoimmune disease or preexisting antibodies not detected by single-antigen bead array due to complement interference or who have been previously treated by desensitization protocols such as rituximab, antithymocyte globulin, or intravenous immunoglobulins.
We report donor and recipient investigations that revealed unexpected positive B-cells crossmatch, probably due to donor cells, as the donor had received rituximab therapy shortly before organ harvesting, in a context of severe idiopathic thrombocytopenic purpura.
We consequently detected unexpected Class II IgG complement-dependent cytotoxicity for all sera tested.
Other laboratory investigations failed to elucidate the reasons for this recipient-related positivity.
American Psychological Association (APA)
Desoutter, Judith& Apithy, Marie-Joëlle& Bartczak, Ségolène& Guillaume, Nicolas. 2016. False Positive B-Cells Crossmatch after Prior Rituximab Exposure of the Kidney Donor. Case Reports in Transplantation،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1102926
Modern Language Association (MLA)
Desoutter, Judith…[et al.]. False Positive B-Cells Crossmatch after Prior Rituximab Exposure of the Kidney Donor. Case Reports in Transplantation No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1102926
American Medical Association (AMA)
Desoutter, Judith& Apithy, Marie-Joëlle& Bartczak, Ségolène& Guillaume, Nicolas. False Positive B-Cells Crossmatch after Prior Rituximab Exposure of the Kidney Donor. Case Reports in Transplantation. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1102926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1102926