Synchronous Malignant Peripheral Nerve Sheath Tumor and Adenocarcinoma of the Prostate: Case Report and Literature Review

Abstract EN

Malignant Peripheral Nerve Sheath Tumors (MPNSTs) of the prostate are extremely rare.

A very unusual case of simultaneous adenocarcinoma and MPNST of the prostate is reported.

A 60-year-old Caucasian male presented for annual urologic examination.

Digital rectal examination revealed a painless, toughish, and asymmetrically enlarged prostate.

Serum prostate-specific antigen was 1 ng/mL.

Radiologic examinations demonstrated a large mass, which was arising from the left peripheral lobe of the prostate.

The patient underwent transrectal ultrasound-guided biopsy of the prostate which revealed a smooth muscle tumor of uncertain malignant potential.

Radical retropubic prostatectomy with en bloc removal of the mass and the seminal vesicles was performed and histology demonstrated low-grade MPNST and adenocarcinoma of the prostate.

To the best of our knowledge, this is the first report of simultaneous prostatic adenocarcinoma and MPNST in the English literature.