Lesser Toxicities of Belotecan in Patients with Small Cell Lung Cancer: A Retrospective Single-Center Study of Camptothecin Analogs
Joint Authors
Park, Yeon Hee
Chung, Chae Uk
Park, Bo Mi
Park, Myoung Rin
Park, Dong Il
Moon, Jae Young
Park, Hee Sun
Kim, Jin Hwan
Jung, Sung Soo
Kim, Ju Ock
Kim, Sun Young
Lee, Jeong Eun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
Topotecan and belotecan are camptothecin derivatives that are used to treat small cell lung cancer (SCLC).
This study compared the toxicities and efficacies of belotecan and topotecan monotherapies in patients with SCLC.
Methods.
We retrospectively reviewed data from 94 patients with SCLC (with or without prior chemotherapy) who were treated using belotecan monotherapy (n=59, 188 cycles) or topotecan monotherapy (n=35, 65 cycles) between September 2003 and December 2011.
Results.
Thrombocytopenia occurred during 42% and 61.5% of the belotecan and topotecan cycles, respectively (p=0.007).
Significant differences between belotecan and topotecan were also observed for grade 4/5 lung infection (3.2% versus 10.8%, resp.; p=0.003), all-grade headache (3.2% versus 10.8%, resp.; p=0.017), and grade 4/5 increased liver enzymes (0.5% versus 4.6%, resp.; p=0.023).
The median TTPDs, CSSs, and OSs were 14 months and 11.6 months (p=0.646), 10 months and 7 months (p=0.179), and 34.5 months and 21.4 months (p=0.914) after belotecan and topotecan monotherapy, respectively.
Conclusions.
Belotecan monotherapy may be safer than topotecan monotherapy in SCLC patients.
And in terms of efficacy, belotecan could be comparable to topotecan monotherapy.
American Psychological Association (APA)
Park, Yeon Hee& Chung, Chae Uk& Park, Bo Mi& Park, Myoung Rin& Park, Dong Il& Moon, Jae Young…[et al.]. 2016. Lesser Toxicities of Belotecan in Patients with Small Cell Lung Cancer: A Retrospective Single-Center Study of Camptothecin Analogs. Canadian Respiratory Journal،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103185
Modern Language Association (MLA)
Park, Yeon Hee…[et al.]. Lesser Toxicities of Belotecan in Patients with Small Cell Lung Cancer: A Retrospective Single-Center Study of Camptothecin Analogs. Canadian Respiratory Journal No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103185
American Medical Association (AMA)
Park, Yeon Hee& Chung, Chae Uk& Park, Bo Mi& Park, Myoung Rin& Park, Dong Il& Moon, Jae Young…[et al.]. Lesser Toxicities of Belotecan in Patients with Small Cell Lung Cancer: A Retrospective Single-Center Study of Camptothecin Analogs. Canadian Respiratory Journal. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103185
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103185