Epicardial Fat: Physiological, Pathological, and Therapeutic Implications
Joint Authors
Mejías, José
Salazar, Juan
Luzardo, Eliana
Ferreira, Antonio
Rivas-Ríos, José Ramón
Bermúdez, Valmore
Rojas, Joselyn
Source
Cardiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Epicardial fat is closely related to blood supply vessels, both anatomically and functionally, which is why any change in this adipose tissue’s behavior is considered a potential risk factor for cardiovascular disease development.
When proinflammatory adipokines are released from the epicardial fat, this can lead to a decrease in insulin sensitivity, low adiponectin production, and an increased proliferation of vascular smooth muscle cells.
These adipokines move from one compartment to another by either transcellular passing or diffusion, thus having the ability to regulate cardiac muscle activity, a phenomenon called vasocrine regulation.
The participation of these adipokines generates a state of persistent vasoconstriction, increased stiffness, and weakening of the coronary wall, consequently contributing to the formation of atherosclerotic plaques.
Therefore, epicardial adipose tissue thickening should be considered a risk factor in the development of cardiovascular disease, a potential therapeutic target for cardiovascular pathology and a molecular point of contact for “endocrine-cardiology.”
American Psychological Association (APA)
Salazar, Juan& Luzardo, Eliana& Mejías, José& Rojas, Joselyn& Ferreira, Antonio& Rivas-Ríos, José Ramón…[et al.]. 2016. Epicardial Fat: Physiological, Pathological, and Therapeutic Implications. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1103273
Modern Language Association (MLA)
Salazar, Juan…[et al.]. Epicardial Fat: Physiological, Pathological, and Therapeutic Implications. Cardiology Research and Practice No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1103273
American Medical Association (AMA)
Salazar, Juan& Luzardo, Eliana& Mejías, José& Rojas, Joselyn& Ferreira, Antonio& Rivas-Ríos, José Ramón…[et al.]. Epicardial Fat: Physiological, Pathological, and Therapeutic Implications. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1103273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103273