Impact of Lifestyle Intervention on HDL-Induced eNOS Activation and Cholesterol Efflux Capacity in Obese Adolescent
Joint Authors
Adams, Volker
Bruyndonckx, Luc
Hoymans, Vicky Y.
Vrints, Christiaan J.
Wesnigk, Jenny
De Guchtenaere, Ann
Fischer, Tina
Schuler, Gerhard
Source
Cardiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Endothelial dysfunction occurs in obese children and adolescent and is regarded as a key step in the development of atherosclerosis.
Important components for the development of endothelial dysfunction are reduced activity of endothelial nitric oxide synthase (eNOS) and an increase in cholesterol deposition in the vessel wall, due to reduced reverse cholesterol transport (RCT) activity.
High density lipoprotein (HDL) exhibits antiatherosclerotic properties including modulation of eNOS activity and cholesterol efflux capacity.
Lifestyle intervention programs can modify endothelial dysfunction in obese adolescents, but their impact on HDL-mediated eNOS activation and RCT is unknown so far.
Methods.
Obese adolescents (15±1 years, BMI > 35 kg/m2) where randomized either to an intervention group (IG, n=8; restricted diet and exercise) or to a usual care group (UC, n=8).
At the beginning and after 10 months of treatment HDL-mediated eNOS phosphorylation and cholesterol efflux capacity were evaluated.
Results.
Ten months of treatment resulted in a substantial weight loss (−31%), an improvement of endothelial function, and an increase in HDL-mediated eNOS-Ser1177 phosphorylation and RCT.
A correlation between change in eNOS-Ser1177 phosphorylation or RCT and change in endothelial function was noted.
Conclusion.
A structured lifestyle intervention program improves antiatherosclerotic HDL functions, thereby positively influencing endothelial function.
American Psychological Association (APA)
Wesnigk, Jenny& Bruyndonckx, Luc& Hoymans, Vicky Y.& De Guchtenaere, Ann& Fischer, Tina& Schuler, Gerhard…[et al.]. 2016. Impact of Lifestyle Intervention on HDL-Induced eNOS Activation and Cholesterol Efflux Capacity in Obese Adolescent. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103278
Modern Language Association (MLA)
Wesnigk, Jenny…[et al.]. Impact of Lifestyle Intervention on HDL-Induced eNOS Activation and Cholesterol Efflux Capacity in Obese Adolescent. Cardiology Research and Practice No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103278
American Medical Association (AMA)
Wesnigk, Jenny& Bruyndonckx, Luc& Hoymans, Vicky Y.& De Guchtenaere, Ann& Fischer, Tina& Schuler, Gerhard…[et al.]. Impact of Lifestyle Intervention on HDL-Induced eNOS Activation and Cholesterol Efflux Capacity in Obese Adolescent. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103278
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103278