Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling
Joint Authors
Bayzigitov, Daniel R.
Medvedev, Sergey P.
Dementyeva, Elena V.
Bayramova, Sevda A.
Pokushalov, Evgeny A.
Karaskov, Alexander M.
Zakian, Suren M.
Source
Cardiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-27
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Fundamental studies of molecular and cellular mechanisms of cardiovascular disease pathogenesis are required to create more effective and safer methods of their therapy.
The studies can be carried out only when model systems that fully recapitulate pathological phenotype seen in patients are used.
Application of laboratory animals for cardiovascular disease modeling is limited because of physiological differences with humans.
Since discovery of induced pluripotency generating induced pluripotent stem cells has become a breakthrough technology in human disease modeling.
In this review, we discuss a progress that has been made in modeling inherited arrhythmias and cardiomyopathies, studying molecular mechanisms of the diseases, and searching for and testing drug compounds using patient-specific induced pluripotent stem cell-derived cardiomyocytes.
American Psychological Association (APA)
Bayzigitov, Daniel R.& Medvedev, Sergey P.& Dementyeva, Elena V.& Bayramova, Sevda A.& Pokushalov, Evgeny A. & Karaskov, Alexander M.…[et al.]. 2016. Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1103280
Modern Language Association (MLA)
Bayzigitov, Daniel R.…[et al.]. Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling. Cardiology Research and Practice No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1103280
American Medical Association (AMA)
Bayzigitov, Daniel R.& Medvedev, Sergey P.& Dementyeva, Elena V.& Bayramova, Sevda A.& Pokushalov, Evgeny A. & Karaskov, Alexander M.…[et al.]. Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1103280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103280