Association between Stable Coronary Artery Disease and In Vivo Thrombin Generation
Joint Authors
Cardoso-Saldaña, Guillermo C.
Valente-Acosta, Benjamin
Baños-González, Manuel Alfonso
Peña-Duque, Marco Antonio
Martínez-Ríos, Marco Antonio
Quintanar-Trejo, Leslie
Aptilon-Duque, Gad
Flores-García, Mirthala
Cruz-Robles, David
de la Peña-Díaz, Aurora
Source
Cardiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Thrombin has been implicated as a key molecule in atherosclerotic progression.
Clinical evidence shows that thrombin generation is enhanced in atherosclerosis, but its role as a risk factor for coronary atherosclerotic burden has not been proven in coronary artery disease (CAD) stable patients.
Objectives.
To evaluate the association between TAT levels and homocysteine levels and the presence of coronary artery disease diagnosed by coronary angiography in patients with stable CAD.
Methods and Results.
We included 95 stable patients admitted to the Haemodynamics Department, including 63 patients with significant CAD and 32 patients without.
We measured the thrombin-antithrombin complex (TAT) and homocysteine concentrations in all the patients.
The CAD patients exhibited higher concentrations of TAT (40.76 μg/L versus 20.81 μg/L, p = 0.002 ) and homocysteine (11.36 μmol/L versus 8.81 μmol/L, p < 0.01 ) compared to the patients without significant CAD.
Specifically, in patients with CAD+ the level of TAT level was associated with the severity of CAD being 36.17 ± 24.48 μg/L in the patients with bivascular obstruction and 42.77 ± 31.81 μg/L in trivascular coronary obstruction, p = 0.002 .
Conclusions.
The level of in vivo thrombin generation, quantified as TAT complexes, is associated with the presence and severity of CAD assessed by coronary angiography in stable CAD patients.
American Psychological Association (APA)
Valente-Acosta, Benjamin& Baños-González, Manuel Alfonso& Peña-Duque, Marco Antonio& Martínez-Ríos, Marco Antonio& Quintanar-Trejo, Leslie& Aptilon-Duque, Gad…[et al.]. 2016. Association between Stable Coronary Artery Disease and In Vivo Thrombin Generation. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103292
Modern Language Association (MLA)
Valente-Acosta, Benjamin…[et al.]. Association between Stable Coronary Artery Disease and In Vivo Thrombin Generation. Cardiology Research and Practice No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1103292
American Medical Association (AMA)
Valente-Acosta, Benjamin& Baños-González, Manuel Alfonso& Peña-Duque, Marco Antonio& Martínez-Ríos, Marco Antonio& Quintanar-Trejo, Leslie& Aptilon-Duque, Gad…[et al.]. Association between Stable Coronary Artery Disease and In Vivo Thrombin Generation. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103292