The Use of IL-1 Receptor Antagonist (Anakinra) in Idiopathic Recurrent Pericarditis: A Narrative Review
Joint Authors
Baskar, Shankar
Klein, Allan L.
Zeft, Andrew
Source
Cardiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Recurrent pericarditis is a complication of acute pericarditis in 20–30% of the patients and is usually idiopathic in nature.
The underlying pathogenesis of this condition remains unclear, although immune-mediated mechanisms seem likely.
A subgroup of these patients with refractory symptoms can be challenging to manage, and multiple immunosuppressive medications have been used without consistent benefit.
Anakinra, an interleukin-1 receptor antagonist, has been used in treatment of rheumatoid arthritis and autoinflammatory syndromes.
Preliminary evidence suggests that anakinra could be a promising therapy for idiopathic recurrent pericarditis.
In this narrative review, we summarize the current understanding of the etiopathogenesis of idiopathic recurrent pericarditis, mechanism of action of anakinra, and the preliminary evidence, supporting the use of anakinra in pericarditis.
American Psychological Association (APA)
Baskar, Shankar& Klein, Allan L.& Zeft, Andrew. 2016. The Use of IL-1 Receptor Antagonist (Anakinra) in Idiopathic Recurrent Pericarditis: A Narrative Review. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103300
Modern Language Association (MLA)
Baskar, Shankar…[et al.]. The Use of IL-1 Receptor Antagonist (Anakinra) in Idiopathic Recurrent Pericarditis: A Narrative Review. Cardiology Research and Practice No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103300
American Medical Association (AMA)
Baskar, Shankar& Klein, Allan L.& Zeft, Andrew. The Use of IL-1 Receptor Antagonist (Anakinra) in Idiopathic Recurrent Pericarditis: A Narrative Review. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103300