Obesity Related Coronary Microvascular Dysfunction: From Basic to Clinical Practice
Joint Authors
Bošnjak, Ivica
Selthofer-Relatić, Kristina
Kibel, A.
Source
Cardiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Obesity related coronary microvascular disease is a medical entity which is not yet fully elucidated.
The pathophysiological basis of coronary microcirculatory dysfunction consists of a heterogeneous group of disorders with individual morphologic/functional/clinical presentation and prognosis.
Coronary microcirculatory changes include mechanisms connected with vascular dysfunction, as well as extravascular and vasostructural changes in responses to neural, mechanical, and metabolic factors.
Cardiometabolic changes that include obesity, dyslipidemia, diabetes mellitus type II, and hypertension are associated with atherosclerosis of epicardial coronary arteries and/or microvascular coronary dysfunction, with incompletely understood underlying mechanisms.
In obesity, microvascular disease is mediated via adipokines/cytokines causing chronic, subclinical inflammation with (a) reduced NO-mediated dilatation, (b) changed endothelial- and smooth muscle-dependent vasoregulating mechanisms, (c) altered vasomotor control with increased sympathetic activity, and (d) obesity related hypertension with cardiomyocytes hypertrophy and impaired cardiac vascular adaptation to metabolic needs.
From a clinical point of view it can present itself in acute or chronic form with different prognosis, as a practice problem for real-life diagnosis and treatment.
American Psychological Association (APA)
Selthofer-Relatić, Kristina& Bošnjak, Ivica& Kibel, A.. 2016. Obesity Related Coronary Microvascular Dysfunction: From Basic to Clinical Practice. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103303
Modern Language Association (MLA)
Selthofer-Relatić, Kristina…[et al.]. Obesity Related Coronary Microvascular Dysfunction: From Basic to Clinical Practice. Cardiology Research and Practice No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103303
American Medical Association (AMA)
Selthofer-Relatić, Kristina& Bošnjak, Ivica& Kibel, A.. Obesity Related Coronary Microvascular Dysfunction: From Basic to Clinical Practice. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103303