Cellular and Molecular Mechanisms of Arrhythmia by Oxidative Stress
Author
Source
Cardiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Current therapies for arrhythmia using ion channel blockade, catheter ablation, or an implantable cardioverter defibrillator have limitations, and it is important to search for new antiarrhythmic therapeutic targets.
Both atrial fibrillation and heart failure, a condition with increased arrhythmic risk, are associated with excess amount of reactive oxygen species (ROS).
There are several possible ways for ROS to induce arrhythmia.
ROS can cause focal activity and reentry.
ROS alter multiple cardiac ionic currents.
ROS promote cardiac fibrosis and impair gap junction function, resulting in reduced myocyte coupling and facilitation of reentry.
In order to design effective antioxidant drugs for treatment of arrhythmia, it is essential to explore the molecular mechanisms by which ROS exert these arrhythmic effects.
Activation of Ca2+/CaM-dependent kinase II, c-Src tyrosine kinase, protein kinase C, and abnormal splicing of cardiac sodium channels are among the recently discovered molecular mechanisms of ROS-induced arrhythmia.
American Psychological Association (APA)
Sovari, Ali A.. 2016. Cellular and Molecular Mechanisms of Arrhythmia by Oxidative Stress. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103308
Modern Language Association (MLA)
Sovari, Ali A.. Cellular and Molecular Mechanisms of Arrhythmia by Oxidative Stress. Cardiology Research and Practice No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103308
American Medical Association (AMA)
Sovari, Ali A.. Cellular and Molecular Mechanisms of Arrhythmia by Oxidative Stress. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103308