Liquid Biopsy of Hepatocellular Carcinoma: Circulating Tumor-Derived Biomarkers
Joint Authors
Chen, Hao
Yuan, Chun-Hui
Guan, Qing
Wang, Fu-Bing
Yin, Chang-Qing
Qu, Zhen
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide due to latent liver disease, late diagnosis, and nonresponse to systemic treatments.
Till now, surgical and/or biopsy specimens are still generally used as a gold standard by the clinicians for clinical decision-making.
However, apart from their invasive characteristics, tumor biopsy only mirrors a single spot of the tumor, failing to reflect current cancer dynamics and progression.
Therefore, it is imperative to develop new diagnostic strategies with significant effectiveness and reliability to monitor high-risk populations and detect HCC at an early stage.
In the past decade, the potent utilities of “liquid biopsy” have attracted intense concern and were developed to evaluate cancer progression in several clinical trials.
“Liquid biopsies” represent a series of noninvasive tests that detect cancer byproducts easily accessible in peripheral blood, mainly including circulating tumor cells (CTCs) and cell-free nucleic acids (cfNAs) that are shed into the blood from the tumor sites.
In this review, we focus on the recent developments in the field of “liquid biopsy” as well as the diagnostic and prognostic significance of CTCs and cfNAs in HCC patients.
American Psychological Association (APA)
Yin, Chang-Qing& Yuan, Chun-Hui& Qu, Zhen& Guan, Qing& Chen, Hao& Wang, Fu-Bing. 2016. Liquid Biopsy of Hepatocellular Carcinoma: Circulating Tumor-Derived Biomarkers. Disease Markers،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1103654
Modern Language Association (MLA)
Yin, Chang-Qing…[et al.]. Liquid Biopsy of Hepatocellular Carcinoma: Circulating Tumor-Derived Biomarkers. Disease Markers No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1103654
American Medical Association (AMA)
Yin, Chang-Qing& Yuan, Chun-Hui& Qu, Zhen& Guan, Qing& Chen, Hao& Wang, Fu-Bing. Liquid Biopsy of Hepatocellular Carcinoma: Circulating Tumor-Derived Biomarkers. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1103654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103654