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The Prognostic Significance of Beta2 Microglobulin in Patients with Hemophagocytic Lymphohistiocytosis
Joint Authors
Jiang, Tiantong
Ding, Xiurong
Lu, Weixing
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To determine the prognostic significance of beta2 microglobulin (β2-m) concentrations in patients with hemophagocytic lymphohistiocytosis (HLH), a rare disorder caused by pathologic activation of the immune system.
Patients and Methods.
The study population consisted of 74 patients diagnosed with HLH and 35 healthy controls.
Serum β2-m levels were measured using a latex agglutination photometric immunoassay.
Results.
Median serum β2-m levels were significantly higher in HLH patients than in healthy controls (4.05 versus 1.5 mg/L; P<0.001) and were significantly higher in patients with lymphoma associated hemophagocytic syndrome (LAHS) than in patients with benign disease-associated HLH (4.2 versus 3.3 mg/L; P<0.001).
Higher serum β2-m levels were positively correlated with LAHS (P=0.005), abnormal lactate dehydrogenase concentrations (P=0.009), and hypoalbuminemia (P=0.003).
ROC analysis showed that overall survival (OS) was significantly shorter in LAHS patients with serum β2-m levels ≥4.03 mg/L compared to <4.03 mg/L (P<0.001).
Moreover, multivariate analysis showed that serum β2-m level was an independent prognostic of OS (P=0.034) in patients with LAHS.
Conclusion.
High serum β2-m levels and LAHS were associated with markedly poorer OS in patients with HLH.
Serum β2-m concentration was a powerful and independent prognostic factor for OS in patients with LAHS.
American Psychological Association (APA)
Jiang, Tiantong& Ding, Xiurong& Lu, Weixing. 2016. The Prognostic Significance of Beta2 Microglobulin in Patients with Hemophagocytic Lymphohistiocytosis. Disease Markers،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103655
Modern Language Association (MLA)
Jiang, Tiantong…[et al.]. The Prognostic Significance of Beta2 Microglobulin in Patients with Hemophagocytic Lymphohistiocytosis. Disease Markers No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103655
American Medical Association (AMA)
Jiang, Tiantong& Ding, Xiurong& Lu, Weixing. The Prognostic Significance of Beta2 Microglobulin in Patients with Hemophagocytic Lymphohistiocytosis. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103655