Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population
Joint Authors
Tang, Sai-sai
Xu, Shun
Cheng, Jie
Cai, Meng-yun
Chen, Lin
Liang, Li-li
Yang, Xi-li
Chen, Can
Liu, Xin-guang
Xiong, Xing-dong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
SIRT6 has been demonstrated to exert protective effects on endothelial cells and is closely associated with lipid metabolism, glucose metabolism, and obesity, indicating an important role in the pathogenesis and progression of coronary artery disease (CAD).
Nonetheless, the biological significance of SIRT6 variants on CAD is far to be elucidated.
Here we aimed to investigate the influence of SIRT6 polymorphisms on individual susceptibility and severity of CAD.
Multivariate logistic regression analysis exhibited no significant association between these five polymorphisms and CAD risk in the genotype and allele frequencies.
However, we found that the rs352493 polymorphism in SIRT6 exhibited a significant effect on the severity of CAD; C allele (χ 2 = 7.793, adjusted P = 0 .
013 ) and the combined CC/CT genotypes (χ 2 = 5.609, adjusted P = 0 .
031 ) presented the greater CAD severity.
In addition, A allele (χ 2 = 5.208, adjusted P = 0 .
046 ) and AA (χ 2 = 4.842, adjusted P = 0 .
054 ) of rs3760908 were also associated with greater CAD severity in Chinese subjects.
Our data provided the first evidence that SIRT6 tagSNPs rs352493 and rs3760908 play significant roles in the severity of CAD in Chinese Han subjects, which might be useful predictors of the severity of CAD.
American Psychological Association (APA)
Tang, Sai-sai& Xu, Shun& Cheng, Jie& Cai, Meng-yun& Chen, Lin& Liang, Li-li…[et al.]. 2016. Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103659
Modern Language Association (MLA)
Tang, Sai-sai…[et al.]. Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103659
American Medical Association (AMA)
Tang, Sai-sai& Xu, Shun& Cheng, Jie& Cai, Meng-yun& Chen, Lin& Liang, Li-li…[et al.]. Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103659