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Identification of Gingival Crevicular Fluid Sampling, Analytical Methods, and Oral Biomarkers for the Diagnosis and Monitoring of Periodontal Diseases: A Systematic Review
Joint Authors
Alabsi, Aied Mohammed
Swaminathan, Dasan
Pushparajan, Saravanan
Nazar Majeed, Zeyad
Philip, Koshy
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-15
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Background.
Several studies in the last decades have focused on finding a precise method for the diagnosis of periodontal disease in its early stages.
Aim.
To evaluate from current scientific literature the most common and precise method for gingival crevicular fluid (GCF) sample collection, biomarker analytical methods, and the variability of biomarker quantification, even when using the same analytical technique.
Methodology.
An electronic search was conducted on in vivo studies that presented clinical data on techniques used for GCF collection and biomarker analysis.
Results.
The results showed that 71.1%, 24.7%, and 4.1% of the studies used absorption, microcapillary, and washing techniques, respectively, in their gingival crevicular fluid collection.
73.1% of the researchers analyzed their samples by using enzyme-linked immunosorbent assay (ELISA).
22.6%, 19.5%, and 18.5% of the researchers included interleukin-1 beta (IL-1β), matrix metalloproteinase-8 (MMP-8), and tumor necrosis factor-alpha (TNF-α), respectively, in their studies as biomarkers for periodontal disease.
Conclusion.
IL-1β can be considered among the most common biomarkers that give precise results and can be used as an indicator of periodontal disease progression.
Furthermore, paper strips are the most convenient and accurate method for gingival crevicular fluid collection, while enzyme-linked immunosorbent assay can be considered the most conventional method for the diagnosis of biofluids.
American Psychological Association (APA)
Nazar Majeed, Zeyad& Philip, Koshy& Alabsi, Aied Mohammed& Pushparajan, Saravanan& Swaminathan, Dasan. 2016. Identification of Gingival Crevicular Fluid Sampling, Analytical Methods, and Oral Biomarkers for the Diagnosis and Monitoring of Periodontal Diseases: A Systematic Review. Disease Markers،Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1103661
Modern Language Association (MLA)
Nazar Majeed, Zeyad…[et al.]. Identification of Gingival Crevicular Fluid Sampling, Analytical Methods, and Oral Biomarkers for the Diagnosis and Monitoring of Periodontal Diseases: A Systematic Review. Disease Markers No. 2016 (2016), pp.1-23.
https://search.emarefa.net/detail/BIM-1103661
American Medical Association (AMA)
Nazar Majeed, Zeyad& Philip, Koshy& Alabsi, Aied Mohammed& Pushparajan, Saravanan& Swaminathan, Dasan. Identification of Gingival Crevicular Fluid Sampling, Analytical Methods, and Oral Biomarkers for the Diagnosis and Monitoring of Periodontal Diseases: A Systematic Review. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1103661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103661