Discovery and Validation of Hypermethylated Markers for Colorectal Cancer
Joint Authors
Wei, Jiufeng
Li, Guodong
Dang, Shuwei
Zhou, Yuhui
Zeng, Kai
Liu, Ming
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Colorectal carcinoma (CRC) is one of the most prevalent malignant tumors worldwide.
Screening and early diagnosis are critical for the clinical management of this disease.
DNA methylation changes have been regarded as promising biomarkers for CRC diagnosis.
Here, we map DNA methylation profiling on CRC in six CRCs and paired normal samples using a 450 K bead array.
Further analysis confirms the methylation status of candidates in two data sets from the Gene Expression Omnibus.
Receiver operating characteristic (ROC) curves are calculated to determine the diagnostic performances.
We identify 1549 differentially methylated regions (DMRs) showing differences in methylation between CRC and normal tissue.
Two genes (ADD2 and AKR1B1), related to the DMRs, are selected for further validation.
ROC curves show that the areas under the curves of ADD2 and AKR1B1 are higher than that of SEPT9, which has been clinically used as a screening biomarker of CRC.
Our data suggests that aberrant DNA methylation of ADD2 and AKR1B1 could be potential screening markers of CRC.
American Psychological Association (APA)
Wei, Jiufeng& Li, Guodong& Dang, Shuwei& Zhou, Yuhui& Zeng, Kai& Liu, Ming. 2016. Discovery and Validation of Hypermethylated Markers for Colorectal Cancer. Disease Markers،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103670
Modern Language Association (MLA)
Wei, Jiufeng…[et al.]. Discovery and Validation of Hypermethylated Markers for Colorectal Cancer. Disease Markers No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103670
American Medical Association (AMA)
Wei, Jiufeng& Li, Guodong& Dang, Shuwei& Zhou, Yuhui& Zeng, Kai& Liu, Ming. Discovery and Validation of Hypermethylated Markers for Colorectal Cancer. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103670