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Pilot Study on MAGE-C2 as a Potential Biomarker for Triple-Negative Breast Cancer
Joint Authors
Zhao, Qian
Xu, Wen-ting
Shalieer, Tuluhong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
In the current study, we measured the expression status of melanoma antigen gene c2 (MAGE-C2) in triple-negative breast cancer (TNBC) and analyzed its prognostic with the clinical pathological features of patients with TNBC.
Methods.
The expressions statuses of MAGE-C2 were detected in TNBC tissues and paracarcinoma tissues by immunohistochemistry, reverse transcription-polymerase chain reaction (RT-PCR), and western blotting.
Then, we investigated the relationship of MAGE-C2 expression status and clinicopathological parameters of TNBC patients by the chi-squared test.
Finally, we discussed the relations of MAGE-C2 expression state and prognosis of patients with TNBC by Kaplan-Meier method and Cox proportional hazards model.
Results.
High MAGE-C2 expression was found in 38.18% (42/110) of TNBC tissues.
In adjacent tissues it was 9.09% (10/110).
High MAGE-C2 expression in TNBC patients was closely associated with lymph node status, tumor node metastasis (TNM) stage, and lymphovascular invasion (P<0.001).
TNBC patients with high MAGE-C2 expression had significantly shorter survival time than low expression patients.
We also found that age, lymph node status, TNM stage, lymphovascular invasion, and MAGE-C2 expression status were closely associated with overall survival of TNBC patients (P<0.05).
Conclusion.
High MAGE-C2 expression may serve as an independent prognostic factor for TNBC patients.
American Psychological Association (APA)
Zhao, Qian& Xu, Wen-ting& Shalieer, Tuluhong. 2016. Pilot Study on MAGE-C2 as a Potential Biomarker for Triple-Negative Breast Cancer. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103671
Modern Language Association (MLA)
Zhao, Qian…[et al.]. Pilot Study on MAGE-C2 as a Potential Biomarker for Triple-Negative Breast Cancer. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103671
American Medical Association (AMA)
Zhao, Qian& Xu, Wen-ting& Shalieer, Tuluhong. Pilot Study on MAGE-C2 as a Potential Biomarker for Triple-Negative Breast Cancer. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103671