Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population

Joint Authors

Zhou, Bin
Liu, Yi
Zhao, Yi
Yu, Xiuzhang
Zhang, Lin
Wang, Yan Yun

Source

Disease Markers

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-02-29

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases

Abstract EN

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease.

IL-32, a secreted protein, has been reported to be associated with several autoimmune diseases.

Our preliminary experiment showed different plasma IL-32 levels than that mentioned in a published report on the same population.

In order to elucidate the correlation between IL-32 and SLE, we determined the plasma level and two single nucleotide polymorphisms (SNPs) of IL-32 in 152 patients with SLE and 310 healthy controls and analyzed the relationship based on the clinical parameters.

The results showed that plasma IL-32 levels in patients with SLE were markedly lower than that in the healthy controls.

In the SLE group, patients with detectable IL-32 presented low serum C3 concentrations.

Further studies indicated that the rs28372698 SNP was associated with the susceptibility to SLE.

Taken together, our results suggested that IL-32 could possibly be a candidate marker to monitor SLE disease stability and screening in future.

American Psychological Association (APA)

Wang, Yan Yun& Zhou, Bin& Zhao, Yi& Yu, Xiuzhang& Liu, Yi& Zhang, Lin. 2016. Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population. Disease Markers،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103673

Modern Language Association (MLA)

Wang, Yan Yun…[et al.]. Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population. Disease Markers No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103673

American Medical Association (AMA)

Wang, Yan Yun& Zhou, Bin& Zhao, Yi& Yu, Xiuzhang& Liu, Yi& Zhang, Lin. Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103673

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1103673