Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population
Joint Authors
Zhou, Bin
Liu, Yi
Zhao, Yi
Yu, Xiuzhang
Zhang, Lin
Wang, Yan Yun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease.
IL-32, a secreted protein, has been reported to be associated with several autoimmune diseases.
Our preliminary experiment showed different plasma IL-32 levels than that mentioned in a published report on the same population.
In order to elucidate the correlation between IL-32 and SLE, we determined the plasma level and two single nucleotide polymorphisms (SNPs) of IL-32 in 152 patients with SLE and 310 healthy controls and analyzed the relationship based on the clinical parameters.
The results showed that plasma IL-32 levels in patients with SLE were markedly lower than that in the healthy controls.
In the SLE group, patients with detectable IL-32 presented low serum C3 concentrations.
Further studies indicated that the rs28372698 SNP was associated with the susceptibility to SLE.
Taken together, our results suggested that IL-32 could possibly be a candidate marker to monitor SLE disease stability and screening in future.
American Psychological Association (APA)
Wang, Yan Yun& Zhou, Bin& Zhao, Yi& Yu, Xiuzhang& Liu, Yi& Zhang, Lin. 2016. Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population. Disease Markers،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103673
Modern Language Association (MLA)
Wang, Yan Yun…[et al.]. Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population. Disease Markers No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103673
American Medical Association (AMA)
Wang, Yan Yun& Zhou, Bin& Zhao, Yi& Yu, Xiuzhang& Liu, Yi& Zhang, Lin. Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103673
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103673